Drug
Information


     


  



Dextropropoxyphene
 

      











 

Pharmacokinetics




Dextropropoxyphene is readily absorbed from the gastrointestinal tract,
the napsylate tending to be more slowly absorbed than the hydrochloride,
but both are subject to considerable first-pass metabolism. Peak plasma
concentrations occur about 1 to 2 hours after ingestion. It is rapidly
distributed and concentrated in the liver, lungs, and brain. About 80%
of dextropropoxyphene and its metabolites are reported to be bound to
plasma proteins. Dextropropoxyphene crosses the placenta. It has been
detected in breast milk but some authorities consider that the amount is
too small to be harmful to a breast-fed infant.


Dextropropoxyphene is N-demethylated
to nordextropropoxyphene (norpropoxyphene), in the liver. It is excreted
in the urine mainly as metabolites. It is now recognised that
dextropropoxyphene and nordextropropoxyphene have prolonged elimination
half-lives; values of 6 to 12 hours and 30 to 36 hours, respectively,
have been reported. Accumulation of dextropropoxyphene and its
metabolites may occur with repeated doses and nordextropropoxyphene may
contribute to the toxicity seen with overdosage.

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Indication &
Dosage


Oral

Acute exacerbations of rheumatoid arthritis or osteoarthritis,
spondylitis, various musculoskeletal conditions with pain: As Hcl 65mg
3-4 times daily usually in conbination with other drugs,

Children : Not recommended usually.

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Action



A relatively week opioid
analgesic. Has no antitussive effect. Usually given in combination with
NSAIDs or other analgesics

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Interaction



Barbiturate anaeshetics: May increase respiratory and CNS depressive
effects of propoxyphene.

Warfarin: Potentiation of hypoprothrombinemic effect.

Carbamazepine: May increase serum carbamazepine levels with resultant
toxicity.

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Adverse
Effect & Precaution




Nausea, Vomiting, epigastric distress and sedation.

Precaution: Additive CNS effects with sedatives. Hypnotics, Barbiturates
and alcohol. Driving and operating machinery.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

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Brands available in
Market




 





Parvodex

Jagsonpal
Caps. 65mg. 10 10.05



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Drug Information
     

  
Dextropropoxyphene
 
      

 
Pharmacokinetics


Dextropropoxyphene is readily absorbed from the gastrointestinal tract, the napsylate tending to be more slowly absorbed than the hydrochloride, but both are subject to considerable first-pass metabolism. Peak plasma concentrations occur about 1 to 2 hours after ingestion. It is rapidly distributed and concentrated in the liver, lungs, and brain. About 80% of dextropropoxyphene and its metabolites are reported to be bound to plasma proteins. Dextropropoxyphene crosses the placenta. It has been detected in breast milk but some authorities consider that the amount is too small to be harmful to a breast-fed infant.
Dextropropoxyphene is N-demethylated to nordextropropoxyphene (norpropoxyphene), in the liver. It is excreted in the urine mainly as metabolites. It is now recognised that dextropropoxyphene and nordextropropoxyphene have prolonged elimination half-lives; values of 6 to 12 hours and 30 to 36 hours, respectively, have been reported. Accumulation of dextropropoxyphene and its metabolites may occur with repeated doses and nordextropropoxyphene may contribute to the toxicity seen with overdosage.

Top
    

Indication & Dosage
Oral
Acute exacerbations of rheumatoid arthritis or osteoarthritis, spondylitis, various musculoskeletal conditions with pain: As Hcl 65mg 3-4 times daily usually in conbination with other drugs,
Children : Not recommended usually.

Top

Action

A relatively week opioid analgesic. Has no antitussive effect. Usually given in combination with NSAIDs or other analgesics

Top
  

Interaction

Barbiturate anaeshetics: May increase respiratory and CNS depressive effects of propoxyphene.
Warfarin: Potentiation of hypoprothrombinemic effect.
Carbamazepine: May increase serum carbamazepine levels with resultant toxicity.

Top
  

Adverse Effect & Precaution

Nausea, Vomiting, epigastric distress and sedation.
Precaution: Additive CNS effects with sedatives. Hypnotics, Barbiturates and alcohol. Driving and operating machinery.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top
 

 

Parvodex

Jagsonpal

Caps.

65mg.

10

10.05

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By |2022-07-20T16:44:43+00:00July 20, 2022|Uncategorized|Comments Off on Dextropropoxyphene

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