Drug Information

     

  



Digoxin

 
 

      












Pharmacokinetics

 




The drug is given orally and absorption is somewhat variable. The
absorption depends on the brand used. The variablility in absorption is
most prominent with tablets of different brands. Digoxin is distributed
to most body tissues and high concentrationis found in cardiac tissue.
Digoxin is excreted primarily by the kidney.

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Indication &
Dosage


 


Oral

Congestive Failure. Atrial fibrillation/Flutter Supraventricular
tachycardia : Adults, Children over 10 year:Initially 0.25-1.5mg daily
according the desired apeed of digitalisation. Maintenance :
0.0625-0.75mg/day. Children below 10 years: Careful buid up of dose
individually. The table may help.






Age Digitalising dose (mcg/kg) Maintenance daily (mcg/kg)
2-5 25-35 25-35% of loading dose
5-10 15-30 25-35% of loading dose
10 8-12 25-35% of loading dose

IV

Congestive Failure. Atrial Fibrillation/Flutter Supraventricular
Tachycardia: Digitalising doses for oral and IV toutes are same.

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Action 

 


Acting as acardiac tonic digoxin increases the force and
speed of systolic contraction of the myocardium, reduces heart rate and
reduces conduction velocity through the AV node. At higher doses digoxin
increases the central sympathetic outflow. Clinically the actions of
digoxin are reflected in increased cardiac output and improvement in
symptoms of congestive failure. Digoxi reduces vetricular rate. In
atrial flutter, sinus rhythm is restored. This culd also happen with
paroxysmal atrial tachycardia(PAT)

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Adverse Effect 

 

Anorexia, nausea, vomiting, diarrhoea, abdominal pain,
fatigue, drowsiness headache, disorientation, confusion, blurred
vision,gynaecomastia,yello vision, photophobia, ventricular abnormal
cardiac rhythms.

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Interaction

 

Serum digoxin levels are increased by : Amiodarone,
Anticholinergics, Benzodiazepines, Captoprill, Esmolol, Flecainide,
Hydroxychloroquine, lbuprofen, Indomethacin, Quinine, Nifedipine,
Tolbutamide & Verapamil.

When the following drugs are disocontinued, digoxin toxicity may
occur:  Aminoglutethimide, Barbiturates, Hydantoin, Phenylbutazone
and Rifampicin, Non-depolarizing muscle relaxants and Succinylcholine :
Toxicity of either agent enhanced when used concomitantly.

Penicillamine : Digoxin efficacy decreased.

Spironlactone : It has unpredictable effect.

Amiloride : Inotropic effects of digoxin decreased. 

Triamterene : Efficacy of digoxin enhanced.

Thaizide & Loop diuretics : cause hypokalaemia which enhance
efficacy and toxicity of digoxin.

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Precaution

 

Hepatic or renal impairment, acute myocardial infarction,
thyrotoxicosis.

Pregnancy : Use with Caution.

Brest Feeding : Use with Caution.

Men : Use with Caution.




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Brands available in
Market




 
















Cardioxin

Novartis
Tab. 0.25mg. 10 x 10 50.00
Inj. 0.5mg./2ml 10ml 19.25
Digitran

Macleods
Tab. 0.25mg. 10 5.85
Digox

Cadila Pharma
Tab. 0.25mg. 10 1.95
Digoxin Inj.

Burroughs Wellcome
Inj. 0.5mg/2ml 2ml 5.31
Digoxin Paed

Burroughs Wellcome
Elix. 0.05mg/ml 30ml 21.03
Lanoxin

Burroughs Wellcome
Tab. 0.25mg. 10 5.85




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Drug Information
     

  
Digoxin   
      

Pharmacokinetics
 

The drug is given orally and absorption is somewhat variable. The absorption depends on the brand used. The variablility in absorption is most prominent with tablets of different brands. Digoxin is distributed to most body tissues and high concentrationis found in cardiac tissue. Digoxin is excreted primarily by the kidney.

Top
   

Indication & Dosage
 

Oral
Congestive Failure. Atrial fibrillation/Flutter Supraventricular tachycardia : Adults, Children over 10 year:Initially 0.25-1.5mg daily according the desired apeed of digitalisation. Maintenance : 0.0625-0.75mg/day. Children below 10 years: Careful buid up of dose individually. The table may help.

Age

Digitalising dose (mcg/kg)

Maintenance daily (mcg/kg)

2-5

25-35

25-35% of loading dose

5-10

15-30

25-35% of loading dose

10

8-12

25-35% of loading dose

IV
Congestive Failure. Atrial Fibrillation/Flutter Supraventricular Tachycardia: Digitalising doses for oral and IV toutes are same.

Top
    

Action 
 

Acting as acardiac tonic digoxin increases the force and speed of systolic contraction of the myocardium, reduces heart rate and reduces conduction velocity through the AV node. At higher doses digoxin increases the central sympathetic outflow. Clinically the actions of digoxin are reflected in increased cardiac output and improvement in symptoms of congestive failure. Digoxi reduces vetricular rate. In atrial flutter, sinus rhythm is restored. This culd also happen with paroxysmal atrial tachycardia(PAT)

Top 
   

Adverse Effect 
 
Anorexia, nausea, vomiting, diarrhoea, abdominal pain, fatigue, drowsiness headache, disorientation, confusion, blurred vision,gynaecomastia,yello vision, photophobia, ventricular abnormal cardiac rhythms.

Top
    

Interaction
 
Serum digoxin levels are increased by : Amiodarone, Anticholinergics, Benzodiazepines, Captoprill, Esmolol, Flecainide, Hydroxychloroquine, lbuprofen, Indomethacin, Quinine, Nifedipine, Tolbutamide & Verapamil.
When the following drugs are disocontinued, digoxin toxicity may occur:  Aminoglutethimide, Barbiturates, Hydantoin, Phenylbutazone and Rifampicin, Non-depolarizing muscle relaxants and Succinylcholine : Toxicity of either agent enhanced when used concomitantly.
Penicillamine : Digoxin efficacy decreased.
Spironlactone : It has unpredictable effect.
Amiloride : Inotropic effects of digoxin decreased. 
Triamterene : Efficacy of digoxin enhanced.
Thaizide & Loop diuretics : cause hypokalaemia which enhance efficacy and toxicity of digoxin.

Top 
  

Precaution
 
Hepatic or renal impairment, acute myocardial infarction, thyrotoxicosis.
Pregnancy : Use with Caution.
Brest Feeding : Use with Caution.
Men : Use with Caution.


Top
   

 

Cardioxin

Novartis

Tab.

0.25mg.

10 x 10

50.00

Inj.

0.5mg./2ml

10ml

19.25

Digitran

Macleods

Tab.

0.25mg.

10

5.85

Digox

Cadila Pharma

Tab.

0.25mg.

10

1.95

Digoxin Inj.

Burroughs Wellcome

Inj.

0.5mg/2ml

2ml

5.31

Digoxin Paed

Burroughs Wellcome

Elix.

0.05mg/ml

30ml

21.03

Lanoxin

Burroughs Wellcome

Tab.

0.25mg.

10

5.85

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By |2022-07-20T16:44:44+00:00July 20, 2022|Uncategorized|Comments Off on Digoxin

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