Drug Information

   




Diltiazem
 
 

  













Pharmacokinetics

 



After oral administration it is highly bound to plasma proteins.
Diltiazem is meta-bolised to active metabolite.





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Indication &
Dosage


 


Oral

Hypertension mild to moderate: 180mg/day in 3 or 4 divided doses. May be
increased upto 240mg/day.

Angina, Chronic Stable, Vasospasti and unstable: Start at 30mg q.i.d
including bedtime dose. Increased as required at intervals of 1 or 2
days upto 240mg/day in 3 to 4 divided doses. 

Prophylaxis of paroxysmal Supraventricular Tachycardias: Upto 240mg/day
in 3 or 4 divided doses. Sustained release forms: Usually 90-120mg b.i.d.
if reqd. Some once daily dose forms also available. 

IV

Atrial Fibrilltion/ Atrial Flutter; PSVT: Initial IV bolus of 0.25mg/kg
over 2mins. If reqd. second individualised as reqd. For continued
reduction of HR in atrial bolus, IV infusion at the rate of 10mg/hr (upto
24hrs). 

NOTE: Elderly: Start with smaller doses and increase very slowly.
Children: Not recommended.


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Action 

  

Ditiazem blocks the ‘L’ type calcium channels which are
present in heart and blood vessels. It reduce heart rate, and blood
pressure in a parallel way. there is no reflex tachycardia. Peripheral
arteries are dilated, resistance and afterload reduced. Coronary vessels
are dilated and there is improvement in collateral circulation.
Spentaneous coronry spasm is prevented. Diltiazem convets paroxysmal
spraventricullar tachycardia to normal sinus rhythm.


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Adverse Effect 

 

Nausea, headache, flushing, oedema, bradycardia, skin rash.

 

Interaction

 


Cimetidine & Ranitidine : Enhance the efficacy of
diltiazem.

B-Blokers : Though advantageous in some, concomitant use may result in
increased adverse effects like bradycardia and conduction disturbances.

Carbamazepine, Cyclosporin Digitalis Glycosides : Efficacy of these
drugs increased with posible toxicity.

Theophylines : Increased efficacy of theophyline.






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Precaution

 


Special Precautions : Abrupt with drewal, renal or hepatic
impairment, log-term use, diabetes, CHF.

Pregnancy : Contraindicated.

Brest Feeding : Use with Caution.

Men : Use with Caution.


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Brands available in
Market




 



















































































Altiazem

Menarini Raunaq
Tab. 30mg 10 18.58
Tab. 60mg. 10 36.13
Angizem

Sun Pharma
Tab. 30mg. 10 19.90
Tab. 60mg. 10 38.00
Cardem

Anglo French
E-R Caps. 90mg. 10 45.00
E-R Caps. 120mg. 10 0.00
E-R Caps. 180mg. 10 84.00
Channel

Micro Labs
Tab. 30mg. 10 18.00
Tab. 60mg. 10 34.90
Coriem XL

Stancare
E-R Caps. 180mg. 10 75.50
E-R Caps. 240mg. 10 90.60
Dicard

Intas
Tab. 30mg. 10 16.50
Tab. 60mg. 10 30.60
Sr-Tab. 90mg. 10 41.25
Dilcal

Boehringer Mannheim
Tab. 30mg. 10 14.75
Tab. 60mg. 10 28.50
Sr-Tab. 90mg. 10 38.50
Dilcardia

Unique
Tab. 30mg. 10 19.63
Tab. 60mg. 10 37.75
Sr-Tab. 90mg. 10 46.81
Sr-Tab. 120mg. 10 57.20
Dilcontin

Modi Mundi Pharma
Tab. 60mg. 10 42.70
Tab. 90mg. 10 60.00
Tab. 120mg. 10 67.80
Dilgrad

Cipla
Tab. 30mg. 10 18.62
Tab. 60mg. 10 36.23
Dilotol

Pace(SOL)
Tab. 30mg. 10 17.59
Tab. 60mg. 10 34.69
Dilter CD

Natco
Tab. 90mg 6 27.61
Tab. 120mg. 6 34.51
Dil Time

Cadila Healthcare
Tab. 30mg. 10 9.95
Tab. 60mg. 10 19.90
Sr-Tab. 90mg. 10 29.00
Sr-Tab. 120mg. 10 35.90
Diltiaz

Plethico
Tab. 30mg. 10 15.14
Tab. 60mg. 10 27.25
Diltisyn

Themis Pharma
Tab. 30mg. 10 15.09
Tab. 60mg. 10 23.38
Dilzem

Torrent
Tab. 30mg. 10 19.50
Tab. 60mg. 10 37.50
Sr-Tab. 90mg. 10 46.90
Inj. 5mg/ml 5ml 17.00
DTM

Biochem
Tab. 30mg. 10 12.07
Tab. 60mg. 10 24.15
Emdil

Malladi Drugs
Tab. 30mg. 10 18.24
Lonozem

Parke-Devis
Tab. 60mg. 10 40.31
Tab. 30mg. 10 20.85
ISKI

Stadmed
F-C Tab. 30mg. 10 19.50
F-C Tab. 60mg. 10 37.50
Sr-Tab. 90mg. 10 46.90
Kaizem

Wockhardt
Caps. 90mg. 7 38.00
Kaizem-CD

Wockhardt
Caps-CR 120mg. 7 54.00
Masdil

Lupin
Tab. 30mg. 10 17.84
Tab. 60mg. 10 34.82
Sefgard

Hidusthan Antibiotics
Tab. 30mg. 10 12.80
Tab. 60mg. 10 26.85






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Drug Information
   

Diltiazem  
  

Pharmacokinetics
 
After oral administration it is highly bound to plasma proteins. Diltiazem is meta-bolised to active metabolite.


Top 
   

Indication & Dosage
 

Oral
Hypertension mild to moderate: 180mg/day in 3 or 4 divided doses. May be increased upto 240mg/day.
Angina, Chronic Stable, Vasospasti and unstable: Start at 30mg q.i.d including bedtime dose. Increased as required at intervals of 1 or 2 days upto 240mg/day in 3 to 4 divided doses. 
Prophylaxis of paroxysmal Supraventricular Tachycardias: Upto 240mg/day in 3 or 4 divided doses. Sustained release forms: Usually 90-120mg b.i.d. if reqd. Some once daily dose forms also available. 
IV
Atrial Fibrilltion/ Atrial Flutter; PSVT: Initial IV bolus of 0.25mg/kg over 2mins. If reqd. second individualised as reqd. For continued reduction of HR in atrial bolus, IV infusion at the rate of 10mg/hr (upto 24hrs). 
NOTE: Elderly: Start with smaller doses and increase very slowly. Children: Not recommended.

Top  
  

Action 
  
Ditiazem blocks the ‘L’ type calcium channels which are present in heart and blood vessels. It reduce heart rate, and blood pressure in a parallel way. there is no reflex tachycardia. Peripheral arteries are dilated, resistance and afterload reduced. Coronary vessels are dilated and there is improvement in collateral circulation. Spentaneous coronry spasm is prevented. Diltiazem convets paroxysmal spraventricullar tachycardia to normal sinus rhythm.

Top   
  

Adverse Effect 
 
Nausea, headache, flushing, oedema, bradycardia, skin rash.

 

Interaction
 
Cimetidine & Ranitidine : Enhance the efficacy of diltiazem.
B-Blokers : Though advantageous in some, concomitant use may result in increased adverse effects like bradycardia and conduction disturbances.
Carbamazepine, Cyclosporin Digitalis Glycosides : Efficacy of these drugs increased with posible toxicity.
Theophylines : Increased efficacy of theophyline.


Top  
   

Precaution
 

Special Precautions : Abrupt with drewal, renal or hepatic impairment, log-term use, diabetes, CHF.
Pregnancy : Contraindicated.
Brest Feeding : Use with Caution.
Men : Use with Caution.

Top  
  

 

Altiazem

Menarini Raunaq

Tab.

30mg

10

18.58

Tab.

60mg.

10

36.13

Angizem

Sun Pharma

Tab.

30mg.

10

19.90

Tab.

60mg.

10

38.00

Cardem

Anglo French

E-R Caps.

90mg.

10

45.00

E-R Caps.

120mg.

10

0.00

E-R Caps.

180mg.

10

84.00

Channel

Micro Labs

Tab.

30mg.

10

18.00

Tab.

60mg.

10

34.90

Coriem XL

Stancare

E-R Caps.

180mg.

10

75.50

E-R Caps.

240mg.

10

90.60

Dicard

Intas

Tab.

30mg.

10

16.50

Tab.

60mg.

10

30.60

Sr-Tab.

90mg.

10

41.25

Dilcal

Boehringer Mannheim

Tab.

30mg.

10

14.75

Tab.

60mg.

10

28.50

Sr-Tab.

90mg.

10

38.50

Dilcardia

Unique

Tab.

30mg.

10

19.63

Tab.

60mg.

10

37.75

Sr-Tab.

90mg.

10

46.81

Sr-Tab.

120mg.

10

57.20

Dilcontin

Modi Mundi Pharma

Tab.

60mg.

10

42.70

Tab.

90mg.

10

60.00

Tab.

120mg.

10

67.80

Dilgrad

Cipla

Tab.

30mg.

10

18.62

Tab.

60mg.

10

36.23

Dilotol

Pace(SOL)

Tab.

30mg.

10

17.59

Tab.

60mg.

10

34.69

Dilter CD

Natco

Tab.

90mg

6

27.61

Tab.

120mg.

6

34.51

Dil Time

Cadila Healthcare

Tab.

30mg.

10

9.95

Tab.

60mg.

10

19.90

Sr-Tab.

90mg.

10

29.00

Sr-Tab.

120mg.

10

35.90

Diltiaz

Plethico

Tab.

30mg.

10

15.14

Tab.

60mg.

10

27.25

Diltisyn

Themis Pharma

Tab.

30mg.

10

15.09

Tab.

60mg.

10

23.38

Dilzem

Torrent

Tab.

30mg.

10

19.50

Tab.

60mg.

10

37.50

Sr-Tab.

90mg.

10

46.90

Inj.

5mg/ml

5ml

17.00

DTM

Biochem

Tab.

30mg.

10

12.07

Tab.

60mg.

10

24.15

Emdil

Malladi Drugs

Tab.

30mg.

10

18.24

Lonozem

Parke-Devis

Tab.

60mg.

10

40.31

Tab.

30mg.

10

20.85

ISKI

Stadmed

F-C Tab.

30mg.

10

19.50

F-C Tab.

60mg.

10

37.50

Sr-Tab.

90mg.

10

46.90

Kaizem

Wockhardt

Caps.

90mg.

7

38.00

Kaizem-CD

Wockhardt

Caps-CR

120mg.

7

54.00

Masdil

Lupin

Tab.

30mg.

10

17.84

Tab.

60mg.

10

34.82

Sefgard

Hidusthan Antibiotics

Tab.

30mg.

10

12.80

Tab.

60mg.

10

26.85

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By |2022-07-20T16:42:32+00:00July 20, 2022|Uncategorized|Comments Off on Diltiazem 

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