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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
It is given by parenteral route (deep i.m. injection) and has short plasma half-life.
Oral
Vertigo, Motion Sickness, Labyrinthitis, Meniere’s Disease, Migraine’s Disease, Migraine Etc.: Adults: 50-100mg 3 to 4 times daily. Children: Over 12 yrs-50mg. 6-12 yrs- 25-50mg.1-6yrs – 12.5 to 25mg. All 2 to 3 times daily.
IM/IV
Prevention and Relief of motion sickness, Treatment of vertigo, Nausea, Vomiting Associated with anesthesia surgery , etc radiation sickness labyrinthine disturbances and post – fenestriation syndrome: 50-100mg repeated after 4-6 hrs. IV: dilute 1ml in 10ml of normal salie and iject over 2minutes. Children: 1.25mg/kg IM q.i.d. Max 300mg/day.
Dimenhydrinate has the typical activity profile of an anthihistamine. It also has an antimuscarinic ad central sedative action. Additionally dimenhydrinate exerts a depressant acton on hyperstimulated labyrinthine function.
Increased blood pressure, burning sensation in lips, mouth and throat. Nausea, vomiting, sweating, pain in chest, throat or hands. Painful sterile abscess at site of injection. Haemolythic anaemia in patients with G6PD enzyme deficiency. Hypertension, tachycardia, salivation, lachrymation, conjuctivitis.
Special Precaution : Impairment of renal function, hypertension. Poisoning due to cadmium or selenium.
Pregnancy : Use only in life threatening acute poisoning.
Brest Feeding : Use only in life threatening acute poisoning.
Men : Use with Caution.
