Drug Information

   





Dinoprostone



  










    

Indication
& Dosage


 


Intravaginal

CERVICAL PRIMING, INDUCTIONAND AUGMENTATION OF LABOUR: 0.5mg
endocervically.



Oral

INDUCTION AND IMPROVING LABOUR: Intially 0.5mg repeated houlrly. Hourly
doses not to exceed 1.5mg

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Action

 

Dinoprostone
when administered intravaginally stimulates the gravid uterus
sufficiently to cause evacuation of uterine contents. The pattern of
uterine contraction is similar to that in normal labour at term.
Dinoprostone can also stimulate smooth muscle of the GI tract.

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Interactions

 

Oxytocics
:  Enhanced efficacy of oxytocics leading to uterine rupture.
Antiprogestins (Epostane, mefipristone) : enhance efficacy of
dinoprostone.

NSAIDs : use the combination cautiously.

Oestrogen : enhances cervical ripening and potentiates efficacy of
dinoprostone when used for terapeutic abortion.

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Adverse
Effect & Precaution





Postpartum haemorrhage, vaginal irritation, nausea, ,
G.I. side effect , amniotic
fluid embolism, uterine hypercontractility, postoperative infection.


 


Epilepsy glaucoma,
asthma, cardiac, he-patic or renal impairment. To monitor foetal hart
rate and uterine pain.

Pregnancy : Contraindicated in the conditions given.

Brest Feeding : NA.

Men : NA.

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Brand
avalible in market









CERVIPRIME

Astra-IDL
SYRINGE 0.5mg 3g 170.96
PRIMIPROST

Astra-IDL
TAB 0.5mg 4 138.14



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Drug Information
   


Dinoprostone
  

    
Indication & Dosage
 
Intravaginal
CERVICAL PRIMING, INDUCTIONAND AUGMENTATION OF LABOUR: 0.5mg endocervically.

Oral
INDUCTION AND IMPROVING LABOUR: Intially 0.5mg repeated houlrly. Hourly doses not to exceed 1.5mg

Top

 

Action
 
Dinoprostone when administered intravaginally stimulates the gravid uterus sufficiently to cause evacuation of uterine contents. The pattern of uterine contraction is similar to that in normal labour at term. Dinoprostone can also stimulate smooth muscle of the GI tract.

Top 

 

Interactions
 
Oxytocics :  Enhanced efficacy of oxytocics leading to uterine rupture. Antiprogestins (Epostane, mefipristone) : enhance efficacy of dinoprostone.
NSAIDs : use the combination cautiously.
Oestrogen : enhances cervical ripening and potentiates efficacy of dinoprostone when used for terapeutic abortion.

Top 

 

Adverse Effect & Precaution

Postpartum haemorrhage, vaginal irritation, nausea, , G.I. side effect , amniotic fluid embolism, uterine hypercontractility, postoperative infection.
 
Epilepsy glaucoma, asthma, cardiac, he-patic or renal impairment. To monitor foetal hart rate and uterine pain.
Pregnancy : Contraindicated in the conditions given.
Brest Feeding : NA.
Men : NA.

Top

 

CERVIPRIME

Astra-IDL

SYRINGE

0.5mg

3g

170.96

PRIMIPROST

Astra-IDL

TAB

0.5mg

4

138.14

Top

 

 

By |2022-07-20T16:44:42+00:00July 20, 2022|Uncategorized|Comments Off on Dinoprostone

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