Drug Information

  


           
       











Pharmacokinetics

 

Like adrenaline 
dobutamine is inactive when given by mouth, and it is rapidly
inactivated in the body by similar processes. It has a half-life of
about 2 minutes. Conjugates of dobutamine and its major metabolite
3-O-methyldobutamine are excreted primarily in urine, with small amounts
eliminated in the faeces.

The primary mechanism of clearance of dobutamine appears to be
distribution to other tissues, and not metabolism or elimination. It has
a half-life of about 2 minutes and plasma concentrations of dobutamine
reach steady-state about 10 to 12 minutes after the start of an
infusion. Dobutamine is used mainly for the short-term treatment of
heart failure and any pharmacokinetic changes in this condition have no
clinical implications in dosage titration. (1)

Steinberg and
Notterman reviewed the pharmacokinetics of dobutamine and other
cardiovascular drugs in children (2) and considered that further study
was required to explain the different findings that had been reported.

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Indication
& Dosage






IV Infusion

INOTROPIC SUPPORT IN INFARCTION, CARDIAC SURGERY, CARDIOMYOPATHIES,
SEPTIC SHOCK, CARDIGENIC SHOCK: 2.5-10mcg/kg/min, adjusted according to
clinical response. Occasionally, infusion rates upt 40mcg/kg/min have
been reqd. to obtain the desired effect.

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Action

 


It is a direct acting inotripic agent whose primary action results from
stimulation of the beta-1 receptors of the heart, while producing
relatively mild chronotropic effects. In patients with depressed cardiac
function, dobutamine increases the stroke volumem and cardiac output
wihtout marked increase in heartrate. Systemic vascular resistance is
usually reduced with dobutamine. Rarely, however, minimum
vasoconstriction has been observed

 

Interactions

 

Bretylium
: Potentiates its action resulting in arrhythmias.

Halogented hydrocarbon anaesthetics : risk of serious arrhythmias.

Oxytocic drugs : May cause persistent hypertension.

TCAs : Use with caution since efficacy of vsopresor enhanced.

Phentolamine & Prazosin : Antagonistic action.

Nitroprusside : Additive effect.

TOP

 
 

Adverse
Effect & Precaution

Increased heart rate. blood pressure and ventricular ectopic
activity. Hypotension, phlebits, nausea, headache, nonspecific 
chest pain, palpitations  and shortness of breath.

 


Special Precaution
: Patients with atrial fibrillation are at risk of developin rapid
ventricular response. Dobutamine may precipitate or exacerbate
ventricular. ectopic activity. During administration of dobutamine
solution, ECG and blood pressure should be continuously monitored.
Hypovolemia should be continuously monitored. Hypovolemia should be
corrected with suitabel volume expanders before treatment with
dobutamine injection is instituted. Dobutamine may cause a marked 
increase in heart rate or blood pressure, especially  systolic
pressure. Usually reduction of dosage promptly reverses these effects.
In patients who become tolerant to dobutamine while receiving continuous
infusion, switching to other drug for several days may allow dobutamine
to be reinstituted.





Pregnancy : Use with Caution.

Brest Feeding : Use with Caution.

Men : Use with Caution.

TOP

 
 

Brand
avalible in market

     






















CARDIJECT INJ-250

Sun Pharma
INJ 250mg/20ml 1x20ml 327.00
CARDIJECT INJ-50

Sun Pharma
INJ 50mg/4ml 5x4ml 80.00
DOBICARD

USV
INJ 250mg/20ml Amp 340.00
DOBUCARE

Criticare
INJ 250mg VIAL 296.97
DOBUCIN

Troikaa
INJ 50mg/ml 5x5ml 1600.00
DOBURAN

Shree Ganesh
INJ 250mg/5ml 5ml 315.00
INJ 250mg/ml 5amps 1245.00
DOBUTREX

Eli Lilly
INJ 250mg VIAL 365.00
KARDIA

Panacea
INJ 250mg/ml 1x5AMP 290.00





     

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Drug Information
  

                   

Pharmacokinetics
 
Like adrenaline  dobutamine is inactive when given by mouth, and it is rapidly inactivated in the body by similar processes. It has a half-life of about 2 minutes. Conjugates of dobutamine and its major metabolite 3-O-methyldobutamine are excreted primarily in urine, with small amounts eliminated in the faeces.
The primary mechanism of clearance of dobutamine appears to be distribution to other tissues, and not metabolism or elimination. It has a half-life of about 2 minutes and plasma concentrations of dobutamine reach steady-state about 10 to 12 minutes after the start of an infusion. Dobutamine is used mainly for the short-term treatment of heart failure and any pharmacokinetic changes in this condition have no clinical implications in dosage titration. (1)
Steinberg and Notterman reviewed the pharmacokinetics of dobutamine and other cardiovascular drugs in children (2) and considered that further study was required to explain the different findings that had been reported.

TOP
  

Indication & Dosage

IV Infusion
INOTROPIC SUPPORT IN INFARCTION, CARDIAC SURGERY, CARDIOMYOPATHIES, SEPTIC SHOCK, CARDIGENIC SHOCK: 2.5-10mcg/kg/min, adjusted according to clinical response. Occasionally, infusion rates upt 40mcg/kg/min have been reqd. to obtain the desired effect.

TOP
  

Action
 
It is a direct acting inotripic agent whose primary action results from stimulation of the beta-1 receptors of the heart, while producing relatively mild chronotropic effects. In patients with depressed cardiac function, dobutamine increases the stroke volumem and cardiac output wihtout marked increase in heartrate. Systemic vascular resistance is usually reduced with dobutamine. Rarely, however, minimum vasoconstriction has been observed

 

Interactions
 
Bretylium : Potentiates its action resulting in arrhythmias.
Halogented hydrocarbon anaesthetics : risk of serious arrhythmias.
Oxytocic drugs : May cause persistent hypertension.
TCAs : Use with caution since efficacy of vsopresor enhanced.
Phentolamine & Prazosin : Antagonistic action.
Nitroprusside : Additive effect.

TOP
 
 

Adverse Effect & Precaution

Increased heart rate. blood pressure and ventricular ectopic activity. Hypotension, phlebits, nausea, headache, nonspecific  chest pain, palpitations  and shortness of breath.

 
Special Precaution : Patients with atrial fibrillation are at risk of developin rapid ventricular response. Dobutamine may precipitate or exacerbate ventricular. ectopic activity. During administration of dobutamine solution, ECG and blood pressure should be continuously monitored. Hypovolemia should be continuously monitored. Hypovolemia should be corrected with suitabel volume expanders before treatment with dobutamine injection is instituted. Dobutamine may cause a marked  increase in heart rate or blood pressure, especially  systolic pressure. Usually reduction of dosage promptly reverses these effects. In patients who become tolerant to dobutamine while receiving continuous infusion, switching to other drug for several days may allow dobutamine to be reinstituted.
Pregnancy : Use with Caution.
Brest Feeding : Use with Caution.
Men : Use with Caution.

TOP
 
 

Brand avalible in market
     

CARDIJECT INJ-250

Sun Pharma

INJ

250mg/20ml

1x20ml

327.00

CARDIJECT INJ-50

Sun Pharma

INJ

50mg/4ml

5x4ml

80.00

DOBICARD

USV

INJ

250mg/20ml

Amp

340.00

DOBUCARE

Criticare

INJ

250mg

VIAL

296.97

DOBUCIN

Troikaa

INJ

50mg/ml

5x5ml

1600.00

DOBURAN

Shree Ganesh

INJ

250mg/5ml

5ml

315.00

INJ

250mg/ml

5amps

1245.00

DOBUTREX

Eli Lilly

INJ

250mg

VIAL

365.00

KARDIA

Panacea

INJ

250mg/ml

1x5AMP

290.00

     

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By |2022-07-20T16:42:30+00:00July 20, 2022|Uncategorized|Comments Off on Dobutamine

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