Drug Information

  


    












Pharmacokinetics

 


In first 24 hours of administration about 70% of halothane is eliminated
unchanged in exhaledgas.

Top

       

Indication
& Dosage


 


Inhalational anaesthesia. In operations where blodd less field is
required.

Dosage: Adults: Induction: :Upto 5% in air, oxygen or oxygen/ nitrous
oxide. Maint: 0.5-1.5%.

Children: Initially give higher % 2.3% then maintain at 0.5-1%.

Top

     

Action



Top

     

Interaction

Adrenaline
and most other sympathomimetics, and theophylline, should be avoided
during halothane anaesthesia since they can produce cardiac arrhythmias;
the risk of arrhythmias is also increased if halothane is used in
patients receiving dopaminergics. The effects of competitive
neuromuscular blockers such as atracurium, and of ganglion blockers such
as pentolinium, pempidine, and trimetaphan are enhanced by halothane and
if required they should be given in reduced dosage. Morphine increases
the depressant effects of halothane on respiration. Chlorpromazine also
enhances the respiratory depressant effect of halothane. The effects of
both ergometrine and oxytocin on the parturient uterus are diminished by
halothane.

Top

     

Adverse
Effect & Precaution




Halothane hepatitis, hepatic necrosis, shivering during recovery.



Precaution: Induction of anaesthesia may be delayed. It sensitizes the
heart to hte actions of catecholamines. Adrenaline to be used with
caution.

Pregnancy: Use only if potential benefit outwighs risk to the foetus.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

Top

     

Brands
available in market


 










 

FLUOTHANE

ICI

LIQUID

50ml

359

LIQUID

250ml

1597.16


Top

     



 






 

   

    
Drug Information
  

    

Pharmacokinetics
 

In first 24 hours of administration about 70% of halothane is eliminated unchanged in exhaledgas.

Top
       

Indication & Dosage
 

Inhalational anaesthesia. In operations where blodd less field is required.
Dosage: Adults: Induction: :Upto 5% in air, oxygen or oxygen/ nitrous oxide. Maint: 0.5-1.5%.
Children: Initially give higher % 2.3% then maintain at 0.5-1%.

Top
     

Action


Top
     

Interaction

Adrenaline and most other sympathomimetics, and theophylline, should be avoided during halothane anaesthesia since they can produce cardiac arrhythmias; the risk of arrhythmias is also increased if halothane is used in patients receiving dopaminergics. The effects of competitive neuromuscular blockers such as atracurium, and of ganglion blockers such as pentolinium, pempidine, and trimetaphan are enhanced by halothane and if required they should be given in reduced dosage. Morphine increases the depressant effects of halothane on respiration. Chlorpromazine also enhances the respiratory depressant effect of halothane. The effects of both ergometrine and oxytocin on the parturient uterus are diminished by halothane.

Top
     

Adverse Effect & Precaution

Halothane hepatitis, hepatic necrosis, shivering during recovery.

Precaution: Induction of anaesthesia may be delayed. It sensitizes the heart to hte actions of catecholamines. Adrenaline to be used with caution.
Pregnancy: Use only if potential benefit outwighs risk to the foetus.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top
     

 

FLUOTHANE

ICI

LIQUID

50ml

359

LIQUID

250ml

1597.16

Top
     

 

 

By |2022-07-20T16:41:17+00:00July 20, 2022|Uncategorized|Comments Off on Halothane

About the Author: