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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations
Precautions |
Brands available in Market
Pharmacokinetics
In first 24 hours of administration about 70% of halothane is eliminated
unchanged in exhaledgas.
Indication
& Dosage
Inhalational anaesthesia. In operations where blodd less field is
required.
Dosage: Adults: Induction: :Upto 5% in air, oxygen or oxygen/ nitrous
oxide. Maint: 0.5-1.5%.
Children: Initially give higher % 2.3% then maintain at 0.5-1%.
Adrenaline and most other sympathomimetics, and theophylline, should be avoided during halothane anaesthesia since they can produce cardiac arrhythmias; the risk of arrhythmias is also increased if halothane is used in patients receiving dopaminergics. The effects of competitive neuromuscular blockers such as atracurium, and of ganglion blockers such as pentolinium, pempidine, and trimetaphan are enhanced by halothane and if required they should be given in reduced dosage. Morphine increases the depressant effects of halothane on respiration. Chlorpromazine also enhances the respiratory depressant effect of halothane. The effects of both ergometrine and oxytocin on the parturient uterus are diminished by halothane.
Adverse
Effect & Precaution
Halothane hepatitis, hepatic necrosis, shivering during recovery.
Precaution: Induction of anaesthesia may be delayed. It sensitizes the
heart to hte actions of catecholamines. Adrenaline to be used with
caution.
Pregnancy: Use only if potential benefit outwighs risk to the foetus.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.
