Drug Information

  


      












Pharmacokinetics

 


It is given by parentral route and on I.V. administration it has
immediate onset of action. It does not

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Indication
& Dosage


 


Prophylaxis of deep vein thrombosis in major surgery prophylaxis and
treatment of venous thrombosis, prophylaxis and treatment of pulmonary
embolism, treatment of atrial fibrillation with embolisation,
prophylaxis and treatment of perpheral arterial embolism.

Dosage: Adults: I.V: 10,000- 12,500 i.u. I.V. stat Maint. Dose: 5000 i.u
4-6 hrs. Also by drip 10,000-20,000 i.u./ lrt of 5% glucose or saline.

I.M: 10,000-12,500 i.u. 8-12hrly deep I.M inj.

Children: Initial 50 i.u/kg/dose I.V drip 4 hrly.

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Action

 

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Interaction

Cephalosporins
increased risk of bleeding. Nitroglycerin: Efficacy of heparain may be
decreased.

Penicillins: Additive effects with heparin, increased risk of bleeding.

Salicylates and dipyridamole increased risk of bleeding.

Digitalis, tetracyclines, antihistamines: May partially inhibit the
anticoagulant effect of heparin.

Lab Tests: Significant elevation of aminotrasferase (AST  &
ALT) levels, errors in measurements of carbon dioxoide pressure,
bicoabonate concentration and base excess may occur when sample fo r gas
analysis contains 10% or more of heparin.

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Adverse
Effect & Precaution




Bleeding, alopecia (reversible), bleeding form gums, unexplained
bruising osteoporosis and rarely hypersenstivity. Thrombocytopenia.
Hyperkalaemia.



Preacaution: Hepatic  or renal dysfunction, oral anticoagulants.
All patients should be screened prior to initiation of heparin therapy
to rule out bleeding disorders. 


Precaution: Use with caution

Pregnancy: May be used.

Breast Feeding: May be used.

Man: May be givenin reduced dose

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Brands
available in market


 













 

BEPARINE

Biological
E


(Heparin sod. 1000/5000 i.u/ml,
Chlorocresol I.P 0.15% w/v) 5ml inj

1000i.u/ml

32.50


5000i.u./ml

98.00

DECLOT

Recon

INJ

5000 i.u


5ml

15.50

INJ


25000 i.u


5ml

63.00


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Drug Information
  

      

Pharmacokinetics
 

It is given by parentral route and on I.V. administration it has immediate onset of action. It does not

Top
     

Indication & Dosage
 

Prophylaxis of deep vein thrombosis in major surgery prophylaxis and treatment of venous thrombosis, prophylaxis and treatment of pulmonary embolism, treatment of atrial fibrillation with embolisation, prophylaxis and treatment of perpheral arterial embolism.
Dosage: Adults: I.V: 10,000- 12,500 i.u. I.V. stat Maint. Dose: 5000 i.u 4-6 hrs. Also by drip 10,000-20,000 i.u./ lrt of 5% glucose or saline.
I.M: 10,000-12,500 i.u. 8-12hrly deep I.M inj.
Children: Initial 50 i.u/kg/dose I.V drip 4 hrly.

Top
     

Action

 

Top
     

Interaction

Cephalosporins increased risk of bleeding. Nitroglycerin: Efficacy of heparain may be decreased.
Penicillins: Additive effects with heparin, increased risk of bleeding.
Salicylates and dipyridamole increased risk of bleeding.
Digitalis, tetracyclines, antihistamines: May partially inhibit the anticoagulant effect of heparin.
Lab Tests: Significant elevation of aminotrasferase (AST  & ALT) levels, errors in measurements of carbon dioxoide pressure, bicoabonate concentration and base excess may occur when sample fo r gas analysis contains 10% or more of heparin.

Top
     

Adverse Effect & Precaution

Bleeding, alopecia (reversible), bleeding form gums, unexplained bruising osteoporosis and rarely hypersenstivity. Thrombocytopenia. Hyperkalaemia.

Preacaution: Hepatic  or renal dysfunction, oral anticoagulants. All patients should be screened prior to initiation of heparin therapy to rule out bleeding disorders. 
Precaution: Use with caution
Pregnancy: May be used.
Breast Feeding: May be used.
Man: May be givenin reduced dose

Top
     

 

BEPARINE

Biological E

(Heparin sod. 1000/5000 i.u/ml, Chlorocresol I.P 0.15% w/v) 5ml inj

1000i.u/ml

32.50

5000i.u./ml

98.00

DECLOT

Recon

INJ

5000 i.u

5ml

15.50

INJ

25000 i.u

5ml

63.00

Top
    

 

 

By |2022-07-20T16:44:42+00:00July 20, 2022|Uncategorized|Comments Off on Heparin

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