Drug Information

  


   
 












Pharmacokinetics

 


The bio-availablity of hydrocortisone is about 50 % after oral
administration. It is metabolised in the hepatic microsomal enzymes. It
is 90% plasma protein bound. The plasma half life is 1.5 hours.



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Indication
& Dosage




IV

ACUTE ADRENO-CORTICAL FAILURE:
100mg 8 hourly.

STATUS ASTHMATICUS: 100-200mg 6hrly

ANAPHYLAXIS: 100-500mg 6 hrly treatment with IM OR SC adrenaline is
recommended.

FULMINANT SYSTEMIC LUPUS:

100-500mg t.i.d.

Intra-articular

JOINT INFLAMMATIONS: 5-50mg inj.

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Action



A
natural corticosteroid used for anti-inflammatory and immunosuppressive
effects as well as hormone replacement therapy, systemic and topical
use. ANti-inflammatory action is independent of the challenge and
depends on the redution in the production of various vasoactive
inflammatory mdediators. The typical effect of systemic steroids include
glucose intolerance, increased catabolism, redistrubutionof dody fat,
lipolysis, sodium and water retention, muscular weakness, osteoporosis,
etc. these are not seen at doses for replacement therapy. Long term use
will lead to suppressionof pituitary-adrenal axis.

 

Interaction

Hydrocortisone has reduced efficacy with concurrent
use of carbamazepine, phenytoin, primidone and barbiturates. It has
enhanced effect in women taking oral contraceptives.

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Adverse
Effect & Precaution

Precaution has to be taken in CCF, hypertension,
diabetes, epilepsy, CRF and in elderly. Longterm use of Hydrocotisone
can cause cushing’s habitus, hyperglycemia, muscular weakness, increased
susceptibility to infection, delayed wound healing, and psychiatric
disturbances.

 

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Brands
available in market






















 


CORT-S


Neon Labs


INJ


10mg/vial


1


134mg


EFCORLIN INJ


Glaxo Allenburys


INJ


100mg


2


32.78


HSS


Shree Ganesh


INJ


100mg


VIAL


31.90


LYCORTIN-S


Lyka


INJ


100mg


VIAL


10.65


PRIMACORT


Macleods


INJ


100mg


VIAL


33.90


INJ


200mg


VIAL


67.90


INJ


400mg


VIAL


133.90


WYCORT


Wyeth Lederle


INJ


25mg/5ml


5MLVIAL


27.15


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Drug Information
  

     

Pharmacokinetics
 

The bio-availablity of hydrocortisone is about 50 % after oral administration. It is metabolised in the hepatic microsomal enzymes. It is 90% plasma protein bound. The plasma half life is 1.5 hours.


Top
  

Indication & Dosage

IV
ACUTE ADRENO-CORTICAL FAILURE:
100mg 8 hourly.
STATUS ASTHMATICUS: 100-200mg 6hrly
ANAPHYLAXIS: 100-500mg 6 hrly treatment with IM OR SC adrenaline is recommended.
FULMINANT SYSTEMIC LUPUS:
100-500mg t.i.d.

Intra-articular
JOINT INFLAMMATIONS: 5-50mg inj.

Top
  

Action

A natural corticosteroid used for anti-inflammatory and immunosuppressive effects as well as hormone replacement therapy, systemic and topical use. ANti-inflammatory action is independent of the challenge and depends on the redution in the production of various vasoactive inflammatory mdediators. The typical effect of systemic steroids include glucose intolerance, increased catabolism, redistrubutionof dody fat, lipolysis, sodium and water retention, muscular weakness, osteoporosis, etc. these are not seen at doses for replacement therapy. Long term use will lead to suppressionof pituitary-adrenal axis.
 

Interaction

Hydrocortisone has reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone and barbiturates. It has enhanced effect in women taking oral contraceptives.

Top
  

Adverse Effect & Precaution

Precaution has to be taken in CCF, hypertension, diabetes, epilepsy, CRF and in elderly. Longterm use of Hydrocotisone can cause cushing’s habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances.

 

Top
  

 

CORT-S

Neon Labs

INJ

10mg/vial

1

134mg

EFCORLIN INJ

Glaxo Allenburys

INJ

100mg

2

32.78

HSS

Shree Ganesh

INJ

100mg

VIAL

31.90

LYCORTIN-S

Lyka

INJ

100mg

VIAL

10.65

PRIMACORT

Macleods

INJ

100mg

VIAL

33.90

INJ

200mg

VIAL

67.90

INJ

400mg

VIAL

133.90

WYCORT

Wyeth Lederle

INJ

25mg/5ml

5MLVIAL

27.15

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By |2022-07-20T16:42:32+00:00July 20, 2022|Uncategorized|Comments Off on Hydrocortisone

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