Drug Information

    


      
  












Pharmacokinetics



After oral administrationit is readily absorbed form GI tract.
Hydroxyurea readily crosses blood brain barrier.

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Indication
& Dosage

 


Oral

CHRONIC MYELOID LEUKAEMIA: 20-30mg/kg day in single doses. Discontinue
if WBC under 3000/mm3 or platelets under 100,000/mm3. Resume when counts
return to normal. 

SOLID TUMOURS: 80mg/kg as a single dose every 3rd day. Monitor blood
counts.

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Action




Cuases cell death by
specific inhibition of DNA synthesis. This action cuases regressions in
chronic myeloid leukemia and other malignancies and psoriasis. The
S-phase-specifec action of hydroxyrea can deplete bone marrow precurso
cells associated with megaloblastic changes.

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Interaction



Lab test: May cause increase in serum uric acid, cratinine and BUN
levels.

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Adverse
Effect & Precaution




Nausea, vomiting, rash , bone marrow depressionis the major toxic
effect. Alopecia, stomatitis, dysuria. Inflammation and increased
pigmentation may occur in areas exposed to radiation. Rare nerurological
disturbances.



Precaution: Monitor hepatic and renal functions. Haematological
monitoring (including bone marrow). Premenopausal women, recent x-ray or
cytotoxic therapy.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be give reduced dose.

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Brands
available in market


 
















 



HYDAB


Dabur


CAPS


500mg


10


145.00


HYDROX-L


BDH


CAPS


500mg


10


78.51


NEODREA


vhb


CAPS


500mg


20


250.00


URDOX


Cadila Healthcare


TAB


500mg


10


106.35


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Drug Information
    

         

Pharmacokinetics

After oral administrationit is readily absorbed form GI tract. Hydroxyurea readily crosses blood brain barrier.

Top
  

Indication & Dosage
 

Oral
CHRONIC MYELOID LEUKAEMIA: 20-30mg/kg day in single doses. Discontinue if WBC under 3000/mm3 or platelets under 100,000/mm3. Resume when counts return to normal. 
SOLID TUMOURS: 80mg/kg as a single dose every 3rd day. Monitor blood counts.

Top
  

Action

Cuases cell death by specific inhibition of DNA synthesis. This action cuases regressions in chronic myeloid leukemia and other malignancies and psoriasis. The S-phase-specifec action of hydroxyrea can deplete bone marrow precurso cells associated with megaloblastic changes.

Top
  

Interaction

Lab test: May cause increase in serum uric acid, cratinine and BUN levels.

Top
 
 

Adverse Effect & Precaution

Nausea, vomiting, rash , bone marrow depressionis the major toxic effect. Alopecia, stomatitis, dysuria. Inflammation and increased pigmentation may occur in areas exposed to radiation. Rare nerurological disturbances.

Precaution: Monitor hepatic and renal functions. Haematological monitoring (including bone marrow). Premenopausal women, recent x-ray or cytotoxic therapy.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be give reduced dose.

Top
  

 

HYDAB

Dabur

CAPS

500mg

10

145.00

HYDROX-L

BDH

CAPS

500mg

10

78.51

NEODREA

vhb

CAPS

500mg

20

250.00

URDOX

Cadila Healthcare

TAB

500mg

10

106.35

Top
 

 

 

By |2022-07-20T16:44:42+00:00July 20, 2022|Uncategorized|Comments Off on Hydroxyurea

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