Drug Information

  


    
 












Pharmacokinetics

 


Hydroxyzine is rapidly absorbed from the gastrointestinal tract and is
metabolised. Metabolites include cetirizine 

which has antihistamine activity. An elimination half-life of about 20
hours has been reported.

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Indication
& Dosage


 


Oral

ANXIETY:
50-100mg q.i.d Children: not recommended.

PRURITUS IN ACUTE AND CHRONIC URTICARIA AND DERMATOSIS: 25mg at night
increased if required up to 25mg  3-4 times a day. Children 6
months-6yrs: 5-15mg at night incrasing to max of 50mg daily in divided
doses. Children over 6 yrs: 15-25mg intitially at night. Increased up to
50-100mg daily. Children under 6 months: Not recommended.




IM


premedication, postoperative relief, adjunct in treatment of acute and
chronic alcholism and withdrawal syndorme: 50-400mg/day as reqd in
divided doses. Children: 1mg/kg daily.

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Action



Depression of subcortical
levels of CNS. Primarily skeletal muscle relaxation, antihistamine and
analgesic effects.

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Interaction

CNS
Depressants (Barbiturates, hypnotics, opiod analgesics): Potentiationof
cns depressant effect.

MAOIs,  TCAs, Atropine: Potentiate anti-muscarinic effects.

Aminoglycoside: Ototoxicity of aminoglycosides masked.

Aminophylline, Benzylpenicillin, Chloramphenicol: Incompatible with
these drugs.

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Adverse
Effect & Precaution





Epigastric distress, nausea, impaired alertness.



Precaution: Renal disease.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be givenin reduced dose

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Brands
available in market

















 


CADISTIN


Cadila Healthcare


TAB


4mg


500


25.79


CEPIAM TR


Natco

TR-CAPS


8mg


10


7.51


PIRITON


Glaxo Pharma


TAB


4mg


500


29.12


POLARAMINE


Fulford


TAB


2mg


240


210.00


SYRUP


0.5mg/ml


60ml


26.20


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Drug Information
  

      

Pharmacokinetics
 

Hydroxyzine is rapidly absorbed from the gastrointestinal tract and is metabolised. Metabolites include cetirizine 
which has antihistamine activity. An elimination half-life of about 20 hours has been reported.

Top
   

Indication & Dosage
 

Oral
ANXIETY:
50-100mg q.i.d Children: not recommended.
PRURITUS IN ACUTE AND CHRONIC URTICARIA AND DERMATOSIS: 25mg at night increased if required up to 25mg  3-4 times a day. Children 6 months-6yrs: 5-15mg at night incrasing to max of 50mg daily in divided doses. Children over 6 yrs: 15-25mg intitially at night. Increased up to 50-100mg daily. Children under 6 months: Not recommended.

IM
premedication, postoperative relief, adjunct in treatment of acute and chronic alcholism and withdrawal syndorme: 50-400mg/day as reqd in divided doses. Children: 1mg/kg daily.

Top
   

Action

Depression of subcortical levels of CNS. Primarily skeletal muscle relaxation, antihistamine and analgesic effects.

Top
   

Interaction

CNS Depressants (Barbiturates, hypnotics, opiod analgesics): Potentiationof cns depressant effect.
MAOIs,  TCAs, Atropine: Potentiate anti-muscarinic effects.
Aminoglycoside: Ototoxicity of aminoglycosides masked.
Aminophylline, Benzylpenicillin, Chloramphenicol: Incompatible with these drugs.

Top
   

Adverse Effect & Precaution

Epigastric distress, nausea, impaired alertness.

Precaution: Renal disease.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be givenin reduced dose

Top
   

 

CADISTIN

Cadila Healthcare

TAB

4mg

500

25.79

CEPIAM TR

Natco

TR-CAPS

8mg

10

7.51

PIRITON

Glaxo Pharma

TAB

4mg

500

29.12

POLARAMINE

Fulford

TAB

2mg

240

210.00

SYRUP

0.5mg/ml

60ml

26.20

Top
  

 

 

By |2022-07-20T16:44:42+00:00July 20, 2022|Uncategorized|Comments Off on Hydroxyzine

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