Drug Information

   

       








Pharmacokinetics

Naproxen, when given orally is highly plasma protein
bound. It gets metabolised in the liver. It has a t1/2 of 12-16
hrs.About 10% gets excreted in the urine. Naproxen enters the brain,
synovial fluid and can cross the placenta.

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Indication and Dosage

Oral

RHEUMATOID ARTHRITIS, OSTEO-ARTHRITIS,
ANKYLOSING SPONDYLITIS, MILD TO MODERATE ACUTE AND PAINFUL MUSCULOSKELETAL
DISORDERS, PRIMARY DYSMENORRHOEA, ACUTE GOUT: Usually 250 mg b.i.d. Acute
gout: 750 mg initially followed by 250 mg 8 hrly.

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Action

Reduces prostaglandin synthesis by inhibiting enzyme
cyclo-oxygenase. Has anti-inflammatory, analgesic and antipyretic action.
Inhibits platelet aggregation.

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Interactions

When Naproxen is used with lithium,
Phenytoin,
anticoagulants and Methotrexate it will increase their toxicity.
It antagonises the effects of diuretics like Frusemide and
Thiazides.

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Precautions

Precaution has to be taken in cardiac failure,
edema, hypertention, elderly and in lactating women.

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Brands available in market :

















Name



ANTESVEL


Martel hammer


TAB


250 mg


10


30.66


ARTAGEN


Ranbaxy


TAB


250 mg


10


33.90


MOVIBON


Brown & Burk


TAB


250 mg


10


39.00


NAPROSYN


RPG


TAB


250 mg


10


26.77


TAB


500 mg


10


54.37


NAPRYN


Themis Pharma


TAB


250 mg


10


33.28


TAB


500 mg


10


66.38


XENOBID

(Naproxen Sodium)


Rallis


TAB


275 mg


10


33.00

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Drug Information
   

       

Pharmacokinetics

Naproxen, when given orally is highly plasma protein bound. It gets metabolised in the liver. It has a t1/2 of 12-16 hrs.About 10% gets excreted in the urine. Naproxen enters the brain, synovial fluid and can cross the placenta.

Top
    

Indication and Dosage

Oral
RHEUMATOID ARTHRITIS, OSTEO-ARTHRITIS, ANKYLOSING SPONDYLITIS, MILD TO MODERATE ACUTE AND PAINFUL MUSCULOSKELETAL DISORDERS, PRIMARY DYSMENORRHOEA, ACUTE GOUT: Usually 250 mg b.i.d. Acute gout: 750 mg initially followed by 250 mg 8 hrly.

Top
    

Action

Reduces prostaglandin synthesis by inhibiting enzyme cyclo-oxygenase. Has anti-inflammatory, analgesic and antipyretic action. Inhibits platelet aggregation.

Top
    

Interactions

When Naproxen is used with lithium, Phenytoin, anticoagulants and Methotrexate it will increase their toxicity. It antagonises the effects of diuretics like Frusemide and Thiazides.

Top
    

Precautions

Precaution has to be taken in cardiac failure, edema, hypertention, elderly and in lactating women.

Top
    

Brands available in market :

Name

ANTESVEL

Martel hammer

TAB

250 mg

10

30.66

ARTAGEN

Ranbaxy

TAB

250 mg

10

33.90

MOVIBON

Brown & Burk

TAB

250 mg

10

39.00

NAPROSYN

RPG

TAB

250 mg

10

26.77

TAB

500 mg

10

54.37

NAPRYN

Themis Pharma

TAB

250 mg

10

33.28

TAB

500 mg

10

66.38

XENOBID
(Naproxen Sodium)

Rallis

TAB

275 mg

10

33.00

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By |2022-07-20T16:44:45+00:00July 20, 2022|Uncategorized|Comments Off on Naproxen

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