Drug Information

      

    







Pharmacokinetics

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Indication and Dosage



Oral

ANGINA PECTORIS-PROPHYLAXIS & TREATMENT: Usual initial dose 10mg b.i.d
(if headache is the problem , 5mg b.i.d initially); usual range 10-20mg
b.i.d; max:30mg b.i.d.

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Action

Its antianginal efficacy is mediated through a unique
dual mode of action. it relaxes the vascular smooth muscle,
firstly-through membrane hyperpolaristion via increased transmembrane
potassium conductance, and secondly-through an increase in intracelluar
cyclic GMP (like nitrates). Its beneficial antianginal effect is
consequent to a combination of increased coronary blood flow via
vasodilation and reduced myocardial oxygen demand via decreased cardiac
preload and afterload. Tolerance is not reported with long-term use of
nicorandil Furthermore, it exhibits cardioprotective effective via
enhancing ischemic preconditioning and inhibiting free radical activity.

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Interactions

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Precautions

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Brands available in market :

















Name



CORFLO


Wockhardt


TABS


5mg


20


99.00


TABS


10mg


20


159.00


KORANDIL


Sun Pharma


TABS


5mg


20


118.00


TABS


10mg


20


180.00


NICORAN


Torrent


TAB


5mg


20


138.00


NIKORAN


Torrent


TAB


5mg


20


138.00


TAB


10mg


20


198.00


ZYNICOR


Cadila Healthcare


TABS


5mg


20


98.00


TABS


10mg


20


161.00

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Drug Information
      

    

Indication and Dosage

Oral
ANGINA PECTORIS-PROPHYLAXIS & TREATMENT: Usual initial dose 10mg b.i.d (if headache is the problem , 5mg b.i.d initially); usual range 10-20mg b.i.d; max:30mg b.i.d.

Top
    

Action

Its antianginal efficacy is mediated through a unique dual mode of action. it relaxes the vascular smooth muscle, firstly-through membrane hyperpolaristion via increased transmembrane potassium conductance, and secondly-through an increase in intracelluar cyclic GMP (like nitrates). Its beneficial antianginal effect is consequent to a combination of increased coronary blood flow via vasodilation and reduced myocardial oxygen demand via decreased cardiac preload and afterload. Tolerance is not reported with long-term use of nicorandil Furthermore, it exhibits cardioprotective effective via enhancing ischemic preconditioning and inhibiting free radical activity.

Top
    

Interactions

Top
    

Precautions

Top
    

Brands available in market :

Name

CORFLO

Wockhardt

TABS

5mg

20

99.00

TABS

10mg

20

159.00

KORANDIL

Sun Pharma

TABS

5mg

20

118.00

TABS

10mg

20

180.00

NICORAN

Torrent

TAB

5mg

20

138.00

NIKORAN

Torrent

TAB

5mg

20

138.00

TAB

10mg

20

198.00

ZYNICOR

Cadila Healthcare

TABS

5mg

20

98.00

TABS

10mg

20

161.00

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By |2022-07-20T16:44:40+00:00July 20, 2022|Uncategorized|Comments Off on Nicorandil

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