Drug Information

  

    







Pharmacokinetics

Nimesulide is not a classical
NSAID, it has weak
action against prostaglandin synthesis [cox-2 inhibitor] but has a
potent Anti-Inflammatory action.It behaves as a competetive inhibitor of
histamine release in-vivo and in-vitro, hence posseses antihistaminic
and antiallergic properties.

Top

   



Indication and Dosage


Oral

PAINFUL INFAMMATORY
CONdDITIONS ASSOCIATED WITH THE MUSCULOSKELETAL SYSTEM, DYMENORRHOES,
THROMBOPHLEBITS, POSTOP AND DENTAL PAIN, ENT INFLAMMATIONS:

Adults usually 100mg b.i.d Children: 5mg/kg/day in 2 or 3 diveded doses.

Top

   

Action

Action is somewhat
different from that of classic NSAIDs. It is a relatively weak inhibitor
of prostaglandin synthesis but has potent antiinflammatory activity. It
acts as a inhibitor of histamine release, and reduces in vitro, superoxide
anion formation by activated neutrophils. May also inhibit release of
tumour necrosis factor alpha and thus reduce the formation of cytokines.

Top

   



Interactions


When Nimesulide is taken along with Cyclosporine, Digitalis
glycosides, Lithium, Methotrexate, Phenytoin there will be
elevated serum levels of these drugs and an increased chance of
adverse effects may occur.

Top

   



Precautions

Those with Alcohol abuse, Colitis, Crohn’s disease,
diverticulitis, gastric ulcer, Diabetes mellitus, Hemorrhoids,
Hepatitis, renal disease, rectal irritation or bleeding, Systemic
lupus erythematosus and Tobacco abuse may have increased chance of
adverse effects.

Top

   



Brands available in market :




























































































































Name

MRP

Manufacturers

ANAFEBRIN

TAB

100mg

10

17.09

Themis

SUSP

50mg/ml

60ml

16.09

Themis

AURONIM

TAB

100mg

10

22.00

Aurobindo Pharma

SUSP

50mg/ml

60ml

13.50

Aurobindo Pharma

SUSP

10mg/ml

60ml

14.25

Aurobindo Pharma

FLEXULID

TAB

100mg

10

20.00

Wander

MAXIFLAM

TAB

100mg

10×10

159.00

Karnataka Antibiotics

SUSP

50mg/ml

60ml

15.00

Karnataka Antibiotics

MAXULIDE

TAB

100mg

10

24.00

Max

MESULID

TAB

100mg

10

19.50

Stadmed

SUSP

50mg/ml

60ml

13.50

Stadmed

MYONAL

TAB

100mg

10

23.45

Uni
Sankyo

MYONAL
SUSP

SUSP

50mg/ml

30ml

13.50

Uni
Sankyo

SUSP

50mg.ml

60ml

16.50

Uni
Sankyo

N-LID

SUSP

50mg/ml

60ml

15.75

Orchid

N-LID
DT

TAB

100mg

10

15.00

Orchid

N-SIDE

TAB

100mg

10

10.00

CFL

SUSP

50mg/ml

60ml

14.00

CFL

NAM

TAB

100mg

20

23.90

Lincoln

SUP

50mg/ml

60ml

17.50

Lincoln

NELSID

TABS

100mg

15×14

490.00

Ind-Swift

NEOSAID

TAB

100mg

10

18.00

Blue
Cross

NILIDE

TAB

100mg

10

23.50

Le
Santa

SUSP

50mg/ml

60ml

17.00

Le
Santa

NIMBID

TAB

100mg

10

19.00

Astra-IDL

NIMEGESIC

TAB

100mg

10

24.15

Alembic

SUSP

50mg/5ml

60ml

14.80

Alembic

SUSP

50mg/5ml

30ml

8.50

Alembic

KID-TAB

50mg

10

14.10

Alembic

NIMERIL
SUSP

SUSP

50mg/ml

10

13.50

Albert

NIMESUL

TAB

100mg

10

19.00

Albert
David

NIMFAST

TAB

100mg

10

9.70

Indon

SUSP

50mg/ml

60ml

16.90

Indon

NIMIND

TAB

100mg

10

15.50

Indoco

SUSP

50mg/ml

50mg/ml

13.79

Indoco

NIMOBID

TAB

100mg

100mg

11.10

Mapra

NIMODOL

TAB

100mg

10

16.75

Aristo

SUSP

50mg/ml

60ml

14.04

Aristo

NIMOTAS-CD

DISP-TABS

100mg

10

17.50

Intas

NIMSAID

TAB

100mg

10

Medley

NIMUFLAM

TAB

100mg

10

18.50

JK
Drug

NIMULID

TAB

100mg

20×10

29.00

Panacea

SUSP

50mg/5ml

60ml

17.00

Panacea

SUSP

50mg/5ml

30ml

8.800

Panacea

NIMULID-MD

TAB

100mg

10×10

29.00

Panacea

NIMUSPA

TABS

100mg

10

22.00

Indoco

NIMUSYP

SUSP

50mg/5ml

60ml

15.90

Centaur

NIMUTAB

TAB

100mg

10

14.50

Centaur

NISE

TAB

100mg

10

23.68

DR.
Reddy’s

KID-TAB

50mg

10

14.47

DR.
Reddy’s

SUSP

10mg/ml

60ml

0.00

DR.
Reddy’s

NIZER

TAB

100mg

10

17.40

USV

NOVOGESIC

TAB

100mg

10

14.80

Glenmark

SUSP

50mg/5ml

60ml

13.70

Glenmark

NOVOLID

TAB

100mg

10

14.80

Brown
& Burk

ORTHOBID

TAB

100mg

10

19.40

Nicholas-Piramal

SUSP

50mg/5ml

60ml

0.00

Nicholas-Piramal

PIRODOL

TAB

100mg

10

17.00

Menarini

SUSP

50mg/5ml

50ml

16.50

Menarini

PRONIM

TAB

100mg

10

11.90

Unichem

PYRANIM

TAB

100mg

10

17.50

Sags
Labs

SUSP

50mg/5ml

60ml

14.50

Sags
Labs

RELISULIDE
SUPS

SUSP

50mg/5ml

60ml

15.35

Juggat

REMULIDE

TAB

100mg

10

24.00

Recon

SUSP

50mg/5ml

60ml

14.70

Recon

SILDE

TABS

100mg

10

20.00

Dee-Pharma

SOONIL

TAB

100mg

10

10.00

Wallace

SOONIL
KID TABS

DIS
TAB

50mg

10

7.00

Wallace

SYSNIDE

TAB

100mg

10

16.50

Systopic

ZOLANDIN

TAB

100mg

10

18.00

SPPL

SUSP

50mg/5ml

60ml

14.70

SPPL

ZYDOL

TAB

100mg

10

15.80

Jenburkt

ZYDOL
SUSP

SUSP

50mg/30ml

30ml

7.50

Jenburkt

Top

  


  

  



 

    

    
Drug Information
  

    

Pharmacokinetics

Nimesulide is not a classical NSAID, it has weak action against prostaglandin synthesis [cox-2 inhibitor] but has a potent Anti-Inflammatory action.It behaves as a competetive inhibitor of histamine release in-vivo and in-vitro, hence posseses antihistaminic and antiallergic properties.

Top
   

Indication and Dosage

Oral
PAINFUL INFAMMATORY CONdDITIONS ASSOCIATED WITH THE MUSCULOSKELETAL SYSTEM, DYMENORRHOES, THROMBOPHLEBITS, POSTOP AND DENTAL PAIN, ENT INFLAMMATIONS:
Adults usually 100mg b.i.d Children: 5mg/kg/day in 2 or 3 diveded doses.

Top
   

Action

Action is somewhat different from that of classic NSAIDs. It is a relatively weak inhibitor of prostaglandin synthesis but has potent antiinflammatory activity. It acts as a inhibitor of histamine release, and reduces in vitro, superoxide anion formation by activated neutrophils. May also inhibit release of tumour necrosis factor alpha and thus reduce the formation of cytokines.

Top
   

Interactions

When Nimesulide is taken along with Cyclosporine, Digitalis glycosides, Lithium, Methotrexate, Phenytoin there will be elevated serum levels of these drugs and an increased chance of adverse effects may occur.

Top
   

Precautions

Those with Alcohol abuse, Colitis, Crohn’s disease, diverticulitis, gastric ulcer, Diabetes mellitus, Hemorrhoids, Hepatitis, renal disease, rectal irritation or bleeding, Systemic lupus erythematosus and Tobacco abuse may have increased chance of adverse effects.

Top
   

Brands available in market :

Name

MRP

Manufacturers

ANAFEBRIN

TAB

100mg

10

17.09

Themis

SUSP

50mg/ml

60ml

16.09

Themis

AURONIM

TAB

100mg

10

22.00

Aurobindo Pharma

SUSP

50mg/ml

60ml

13.50

Aurobindo Pharma

SUSP

10mg/ml

60ml

14.25

Aurobindo Pharma

FLEXULID

TAB

100mg

10

20.00

Wander

MAXIFLAM

TAB

100mg

10×10

159.00

Karnataka Antibiotics

SUSP

50mg/ml

60ml

15.00

Karnataka Antibiotics

MAXULIDE

TAB

100mg

10

24.00

Max

MESULID

TAB

100mg

10

19.50

Stadmed

SUSP

50mg/ml

60ml

13.50

Stadmed

MYONAL

TAB

100mg

10

23.45

Uni Sankyo

MYONAL SUSP

SUSP

50mg/ml

30ml

13.50

Uni Sankyo

SUSP

50mg.ml

60ml

16.50

Uni Sankyo

N-LID

SUSP

50mg/ml

60ml

15.75

Orchid

N-LID DT

TAB

100mg

10

15.00

Orchid

N-SIDE

TAB

100mg

10

10.00

CFL

SUSP

50mg/ml

60ml

14.00

CFL

NAM

TAB

100mg

20

23.90

Lincoln

SUP

50mg/ml

60ml

17.50

Lincoln

NELSID

TABS

100mg

15×14

490.00

Ind-Swift

NEOSAID

TAB

100mg

10

18.00

Blue Cross

NILIDE

TAB

100mg

10

23.50

Le Santa

SUSP

50mg/ml

60ml

17.00

Le Santa

NIMBID

TAB

100mg

10

19.00

Astra-IDL

NIMEGESIC

TAB

100mg

10

24.15

Alembic

SUSP

50mg/5ml

60ml

14.80

Alembic

SUSP

50mg/5ml

30ml

8.50

Alembic

KID-TAB

50mg

10

14.10

Alembic

NIMERIL SUSP

SUSP

50mg/ml

10

13.50

Albert

NIMESUL

TAB

100mg

10

19.00

Albert David

NIMFAST

TAB

100mg

10

9.70

Indon

SUSP

50mg/ml

60ml

16.90

Indon

NIMIND

TAB

100mg

10

15.50

Indoco

SUSP

50mg/ml

50mg/ml

13.79

Indoco

NIMOBID

TAB

100mg

100mg

11.10

Mapra

NIMODOL

TAB

100mg

10

16.75

Aristo

SUSP

50mg/ml

60ml

14.04

Aristo

NIMOTAS-CD

DISP-TABS

100mg

10

17.50

Intas

NIMSAID

TAB

100mg

10

Medley

NIMUFLAM

TAB

100mg

10

18.50

JK Drug

NIMULID

TAB

100mg

20×10

29.00

Panacea

SUSP

50mg/5ml

60ml

17.00

Panacea

SUSP

50mg/5ml

30ml

8.800

Panacea

NIMULID-MD

TAB

100mg

10×10

29.00

Panacea

NIMUSPA

TABS

100mg

10

22.00

Indoco

NIMUSYP

SUSP

50mg/5ml

60ml

15.90

Centaur

NIMUTAB

TAB

100mg

10

14.50

Centaur

NISE

TAB

100mg

10

23.68

DR. Reddy’s

KID-TAB

50mg

10

14.47

DR. Reddy’s

SUSP

10mg/ml

60ml

0.00

DR. Reddy’s

NIZER

TAB

100mg

10

17.40

USV

NOVOGESIC

TAB

100mg

10

14.80

Glenmark

SUSP

50mg/5ml

60ml

13.70

Glenmark

NOVOLID

TAB

100mg

10

14.80

Brown & Burk

ORTHOBID

TAB

100mg

10

19.40

Nicholas-Piramal

SUSP

50mg/5ml

60ml

0.00

Nicholas-Piramal

PIRODOL

TAB

100mg

10

17.00

Menarini

SUSP

50mg/5ml

50ml

16.50

Menarini

PRONIM

TAB

100mg

10

11.90

Unichem

PYRANIM

TAB

100mg

10

17.50

Sags Labs

SUSP

50mg/5ml

60ml

14.50

Sags Labs

RELISULIDE SUPS

SUSP

50mg/5ml

60ml

15.35

Juggat

REMULIDE

TAB

100mg

10

24.00

Recon

SUSP

50mg/5ml

60ml

14.70

Recon

SILDE

TABS

100mg

10

20.00

Dee-Pharma

SOONIL

TAB

100mg

10

10.00

Wallace

SOONIL KID TABS

DIS TAB

50mg

10

7.00

Wallace

SYSNIDE

TAB

100mg

10

16.50

Systopic

ZOLANDIN

TAB

100mg

10

18.00

SPPL

SUSP

50mg/5ml

60ml

14.70

SPPL

ZYDOL

TAB

100mg

10

15.80

Jenburkt

ZYDOL SUSP

SUSP

50mg/30ml

30ml

7.50

Jenburkt

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By |2022-07-20T16:42:34+00:00July 20, 2022|Uncategorized|Comments Off on Nimesulide

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