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Cardiology


 


   





Atrial
Fibrillation

     

  • Daoud
    EG, Strickberger SA, Man KC, et al


    Preoperative Amiodarone As Prophylaxis Against Atrial Fibrillation After Heart Surgery


    N Engl J Med 337: 1785-1791, 1997

      


    Postoperative atrial fibrillation can occur in as many as 40% of patients having cardiac surgery. Amiodarone is effective against atrial fibrillation therefore the oral use of amiodarone as prophylaxis against postoperative atrial fibrillation was investigated in a double-blind randomizes study.

      


    124 patients undergoing cardiac surgery [ 84 men] received either 600 mg oral amiodarone daily [ n=64] or placebo [n=60] for an average of 12 days before surgery. Patients receiving amiodarone before surgery also received 200 mg of it daily after surgery until discharge.

       


    Postoperatively significantly fewer amiodarone patients than placebo patients had atrial fibrillation [25% vs 53%]. During hospitalization also the same observation was made [amiodarone 23% vs placebo 42%]. The maximal heart rates during atrial fibrillation were significantly lower in the amiodarone group than the placebo group [ 112 vs 135 beats per minute]. Duration of atrial fibrillation was similar in the two groups. The use of beta-blockers made no difference in the prevalence of atrial fibrillation. Patients having valvular surgery had higher incidence of atrial fibrillation than those undergoing coronary bypass surgery [46% vs 29%]. Patients in the placebo group had a significantly longer stay in the hospital [7.9 vs 6.5 days]. The incidence of other postoperative complications was the same in both groups. Morbidity occurred in 6 placebo patients and 8 amiodarine patients. Two placebo and three amiodarone patients died. Five placebo and one amiodarone patient had malignant ventricular arrhythmias. Amiodarone patients had significantly lower hospital costs than the placebo patients.

       


    Thus low dose amiodarone taken prophylactically significantly reduced the incidence of atrial fibrillation and the cost of hospitalisation in cardiac surgery patients.

         




 

 

Speciality Spotlight

 

   

Atrial Fibrillation
     

  • Daoud EG, Strickberger SA, Man KC, et al
    Preoperative Amiodarone As Prophylaxis Against Atrial Fibrillation After Heart Surgery
    N Engl J Med 337: 1785-1791, 1997
      
    Postoperative atrial fibrillation can occur in as many as 40% of patients having cardiac surgery. Amiodarone is effective against atrial fibrillation therefore the oral use of amiodarone as prophylaxis against postoperative atrial fibrillation was investigated in a double-blind randomizes study.
      
    124 patients undergoing cardiac surgery [ 84 men] received either 600 mg oral amiodarone daily [ n=64] or placebo [n=60] for an average of 12 days before surgery. Patients receiving amiodarone before surgery also received 200 mg of it daily after surgery until discharge.
       
    Postoperatively significantly fewer amiodarone patients than placebo patients had atrial fibrillation [25% vs 53%]. During hospitalization also the same observation was made [amiodarone 23% vs placebo 42%]. The maximal heart rates during atrial fibrillation were significantly lower in the amiodarone group than the placebo group [ 112 vs 135 beats per minute]. Duration of atrial fibrillation was similar in the two groups. The use of beta-blockers made no difference in the prevalence of atrial fibrillation. Patients having valvular surgery had higher incidence of atrial fibrillation than those undergoing coronary bypass surgery [46% vs 29%]. Patients in the placebo group had a significantly longer stay in the hospital [7.9 vs 6.5 days]. The incidence of other postoperative complications was the same in both groups. Morbidity occurred in 6 placebo patients and 8 amiodarine patients. Two placebo and three amiodarone patients died. Five placebo and one amiodarone patient had malignant ventricular arrhythmias. Amiodarone patients had significantly lower hospital costs than the placebo patients.
       
    Thus low dose amiodarone taken prophylactically significantly reduced the incidence of atrial fibrillation and the cost of hospitalisation in cardiac surgery patients.
         

 

By |2022-07-20T16:44:32+00:00July 20, 2022|Uncategorized|Comments Off on Atrial Fibrillation

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