Speciality
Spotlight

 




 


Cardiology


 


   





Chronic Stable Angina

    

  • S. Hashimoto, E. Yamauchi, et al (Department of Intensive Care, Japan)

    The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina.

    Br.J.Cl. Pharmacol. Oct.2000, 50(4), 373-376.

      

    Summary: Trinitroglycerin (GTN) or glyceryl trinitrate is widely used in patients in intensive care setting. It is given intravenously to patients of coronary artery disease. When such patients are stable and transferred to general ward, GTN tapes are substituted for IV GTN for convenience.

       

    In this study, cardiovascular parameters and GTN along with its 4 metabolites were estimated for 24 hours during application of GTN tapes.

       

    A major benefit of transdermal administration of GTN is that it avoids first-pass metabolism by the liver. Continuous use of transdermal patch can lead to nitrate tolerance. So, it may be used only during daytime.

      

    This study has documented the pharmacokinetics of GTN and its metabolites during application of GTN transdermally and after GTN infusion in patients with chronic stable angina. The results indicate that transdermal GTN would maintain adequate therapeutic concentration of GTN after it substitutes intravenous GTN.

        




 

 

Speciality Spotlight

 

   

Chronic Stable Angina
    

  • S. Hashimoto, E. Yamauchi, et al (Department of Intensive Care, Japan)
    The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina.
    Br.J.Cl. Pharmacol. Oct.2000, 50(4), 373-376.
      
    Summary: Trinitroglycerin (GTN) or glyceryl trinitrate is widely used in patients in intensive care setting. It is given intravenously to patients of coronary artery disease. When such patients are stable and transferred to general ward, GTN tapes are substituted for IV GTN for convenience.
       
    In this study, cardiovascular parameters and GTN along with its 4 metabolites were estimated for 24 hours during application of GTN tapes.
       
    A major benefit of transdermal administration of GTN is that it avoids first-pass metabolism by the liver. Continuous use of transdermal patch can lead to nitrate tolerance. So, it may be used only during daytime.
      
    This study has documented the pharmacokinetics of GTN and its metabolites during application of GTN transdermally and after GTN infusion in patients with chronic stable angina. The results indicate that transdermal GTN would maintain adequate therapeutic concentration of GTN after it substitutes intravenous GTN.
        

 

By |2022-07-20T16:42:40+00:00July 20, 2022|Uncategorized|Comments Off on Chronic Stable Angina

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