Speciality
Spotlight

 




 


Cardiology


 


   





Thrombolytic Therapy

      

  • Shamir R Mehta, John W Eikelboom (Division of Cardiology and the Population Health Institute, Hamilton Health Sciences Corporation, McMaster University, Canada)

    Risk of Intracranial haemorrhage with bolus versus infusion thrombolytic therapy: a meta-analysis.

    Lancet August 5, 2000; 356: 449-54.

            

    Thrombolytic therapy given by bolus injection seems to be as effective as infusion over 60-90min. No single trial has been adequately powered to clinically detect important safety differences between the 2 methods. Authors have done a meta-analysis to find out whether bolus administration of thrombolytics is associated with an increased frequency of intracranial haemorrhage.

        

    Seven trials involving a total of 103972 patients were included. Bolus treatment was associated with an increased risk of intracranial haemorrhage compared with infusion. The increased risk was most striking in trials comparing bolus with infusion administration of the same agent but was also evident in trials comparing a newer-generation bolus agent with standard infusion therapy. The rates of non-haemorrhagic stroke, 30 day mortality and reinfarction did not differ between the 2 methods.

        




 

 

Speciality Spotlight

 

   

Thrombolytic Therapy
      

  • Shamir R Mehta, John W Eikelboom (Division of Cardiology and the Population Health Institute, Hamilton Health Sciences Corporation, McMaster University, Canada)
    Risk of Intracranial haemorrhage with bolus versus infusion thrombolytic therapy: a meta-analysis.
    Lancet August 5, 2000; 356: 449-54.
            
    Thrombolytic therapy given by bolus injection seems to be as effective as infusion over 60-90min. No single trial has been adequately powered to clinically detect important safety differences between the 2 methods. Authors have done a meta-analysis to find out whether bolus administration of thrombolytics is associated with an increased frequency of intracranial haemorrhage.
        
    Seven trials involving a total of 103972 patients were included. Bolus treatment was associated with an increased risk of intracranial haemorrhage compared with infusion. The increased risk was most striking in trials comparing bolus with infusion administration of the same agent but was also evident in trials comparing a newer-generation bolus agent with standard infusion therapy. The rates of non-haemorrhagic stroke, 30 day mortality and reinfarction did not differ between the 2 methods.
        

 

By |2022-07-20T16:44:22+00:00July 20, 2022|Uncategorized|Comments Off on Thrombolytic Therapy

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