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Speciality Spotlight
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Hugh R watson, Allan M Skene, & Glyn Belcher (Searle European Clinical R&D Paris, France, Nottingham Clinical Trial Data Centre, Nottingham & Takeda European R&D Centre, London, UK)
Graft material and results of platelet inhibitor trials in peripheral arterial reconstrcutions: reappraisal of results from a meta-analysis.
Br.J Clin.Pharmacol, 49, 479-483.
After bypass procedures, platelet inhibitors are administered with an object of maintaining graft patency. The use of aspirin and related platelet inhibitors in clinical trials showed that there is little evidence that antiplatelet agents prevent occlusion of vein grafts.
It is possible that the platelet inhibitors may have some effect on the prosthetic grafts themselves.
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Manon E Cromheecke, Marcel Levi, et al (Department of Cardiopulmonary Surgery, vascular Medicine, Department of Internal Medicine, and Department of Clinical Epidemiology and Biostatistics. Academic Medical Centre, University of Amsterdam, Netherlands)
Oral anticoagulation self-management and management by a specialist anticoagulation clinic: a randomized cross-over comparison.
Lancet. Vol.356, July 8, 2000, p.97-102
± 50.5 INR units).
The findings showed that there was no significant difference in the overall quality of anticoagulation between the 2 study periods.
Self-management of anticoagulation appears feasible and appears equivalent to management by a specialist anticoagulation centre.