|
Speciality Spotlight
Bladder
Tumour
- M.C.Hayes, B.R. Birch, A.J. Cooper and J.N. Primrose [ Departments of Urology and University Department of Surgery, Southampton General Hospital, Southampton, UK]
Cellular Resistance to Mitomycin C is Associated with Overexpression of MDR-1 in a Urothelial Cancer Cell Line [ MGH-U1]
BJU International, volume 87, Number 3, February 2001, Pg.Nos. 245-250
Conclusion – Urothelial cancer cell resistance to mitomycin C is associated with cross resistance to epirubicin and overexpression of MDR-1, suggesting that mitomycin C falls within the MDR category. Clinical application of this methodology may allow patients to be identified who are unlikely to benefit from intravesical chemotherapy