Speciality
Spotlight

 




           

Clinical Pharmacology

       

     





Choriocarcinoma

   

  • Michael J
    Secki, Rosemary A Fisher et al (Department of
    Medical Oncology, Histopathology and Cancer Cell
    Biology, London, UK)





    Choriocarcinoma and
    partial hydatidiform moles


    Lancet, vol.356,
    July 1, 2000, pg.36-39.

     

    Partial hydatidiform moles (PMS) rarely require
    chemotherapy and have never previously been proven
    to transform into choriocarcinoma, the most
    malignant form of gestational trophoblastic disease
    (GTD). Whether
    women with PMD need human chorionic gonadotrophin (hCG)
    follow-up is debated. The authors have investigated whether PMS can
    transform into choriocarcinoma.


     


    Patients
    with a PM who developed a subsequent choriocarcinoma
    were identified from the author’s GTD database. Histology of both PM and ensuing
    choriocarcinoma was reviewed and flow cytometry used
    to verify the triploid status of the PMS. Complete hydatidiform moles (CMS) are diploid
    and nearly always androgenic in origin, whereas PMS
    are triploid consisting of 1 maternal and 2 paternal
    sets of chromosomes.
    To determine whether choriocarcinoma arose
    from the PM, DNA form the PM and choriocarcinoma in
    each patient was compared.




      

    Of the 3000
    patients with PM, 15 required chemotherapy for
    persisting GTD. This was identified as choriocarcinoma in 3 cases.

      

    These
    results show that PMS can transform into
    choriocarcinoma. All patients, with suspected PM should be
    reviewed and if confirmed, need hCG follow-up.



  
 



 

     

Speciality Spotlight

 

           
Clinical Pharmacology
       

     

Choriocarcinoma
   

  • Michael J Secki, Rosemary A Fisher et al (Department of Medical Oncology, Histopathology and Cancer Cell Biology, London, UK)


    Choriocarcinoma and partial hydatidiform moles
    Lancet, vol.356, July 1, 2000, pg.36-39.
     
    Partial hydatidiform moles (PMS) rarely require chemotherapy and have never previously been proven to transform into choriocarcinoma, the most malignant form of gestational trophoblastic disease (GTD). Whether women with PMD need human chorionic gonadotrophin (hCG) follow-up is debated. The authors have investigated whether PMS can transform into choriocarcinoma.
     
    Patients with a PM who developed a subsequent choriocarcinoma were identified from the author’s GTD database. Histology of both PM and ensuing choriocarcinoma was reviewed and flow cytometry used to verify the triploid status of the PMS. Complete hydatidiform moles (CMS) are diploid and nearly always androgenic in origin, whereas PMS are triploid consisting of 1 maternal and 2 paternal sets of chromosomes. To determine whether choriocarcinoma arose from the PM, DNA form the PM and choriocarcinoma in each patient was compared.


      
    Of the 3000 patients with PM, 15 required chemotherapy for persisting GTD. This was identified as choriocarcinoma in 3 cases.
      
    These results show that PMS can transform into choriocarcinoma. All patients, with suspected PM should be reviewed and if confirmed, need hCG follow-up.

    

 

By |2022-07-20T16:44:01+00:00July 20, 2022|Uncategorized|Comments Off on Choriocarcinoma

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