Iain B Squire & David B. Barnett (Department of Medicine and Therapeutics, University of Leicester, UK)
The rational use of b-adrenoceptor blockers in the treatment of heart failure. The changing face of an old therapy.
Br.J.Clin Pharmacol, 49, 1-9.
Summary : The concept of using beta-blockers in the treatment of heart failure was introduced in the 1970s. There is a common belief that beta-blockade is contraindicated in treatment of patients with stable chronic heart failure.
The case for a beneficial effect of beta-blockade in patients with stable, chronic heart failure is established. Available data pertains to mild to moderate heart failure. Studies have shown benefit in terms of morbidity and mortality.