Speciality
Spotlight

 




           

Clinical Pharmacology

       

     





Liver Microsomes

   

  • Mei Zhang,  J.
    Paul Fawcett et al (School of Pharmacy, University
    of Otago, Dunedine, New Zealand)


     

    Stereoselective glucuronidation of formoterol by
    human liver microsomes.




    Br.J.Clin.Pharmacol, 49, 152-157.


     

      

    Summary :
    Formoterol is a beta-adrenoceptor agonist marketed
    as a racemic mixture of the active and inactive
    enantiomers. It
    produces bronchodilatation but there is market
    interpatient variability in duration of effect. It is metabolised by conjugation with
    glucuronic acid. In this study, human liver microsomes have
    been used to investigate glucuronidation of
    formoterol enantiomers.




      

    This study
    shows that glucuronidation of formoterol by liver
    microsomes is stereoselective and subject to high
    interindividual variability. This may explain the variation in duration of
    bronchodilation produced by Formoterol in patients
    of asthma.

      




  
 



 

     

Speciality Spotlight

 

           
Clinical Pharmacology
       

     

Liver Microsomes
   

  • Mei Zhang,  J. Paul Fawcett et al (School of Pharmacy, University of Otago, Dunedine, New Zealand)

     

    Stereoselective glucuronidation of formoterol by human liver microsomes.


    Br.J.Clin.Pharmacol, 49, 152-157.

     

      
    Summary : Formoterol is a beta-adrenoceptor agonist marketed as a racemic mixture of the active and inactive enantiomers. It produces bronchodilatation but there is market interpatient variability in duration of effect. It is metabolised by conjugation with glucuronic acid. In this study, human liver microsomes have been used to investigate glucuronidation of formoterol enantiomers.


      
    This study shows that glucuronidation of formoterol by liver microsomes is stereoselective and subject to high interindividual variability. This may explain the variation in duration of bronchodilation produced by Formoterol in patients of asthma.
      

    

 

By |2022-07-20T16:43:59+00:00July 20, 2022|Uncategorized|Comments Off on Liver Microsomes

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