Reynard JM Cannon A, Yang Q, et al [The Royal London Hosp; Southmead, Hosp, Bristol, England]
A Novel Therapy for Nocturnal Polyuria: A Double-blind Randomized Trial of Frusemide Against Placebo
Br J Urol 81: 215-218, 1998
Background – Elderly individuals excrete a larger proportion of their 24 hour urine volume at night compared with younger individuals. As many as 1/4th of men with lower urinary tract symptoms reportedly have nocturnal polyuria. The efficacy of an afternoon dose of the diuretic furosemide in establishing early evening diuresis and thus decreasing nocturnal voiding frequency and voided volume in elderly men with LUTS was assessed.
Conclusions – A frequency volume chart should be given to men with whose most prominent symptom is nocturia. In those with nocturnal polyuria, 40 mg dose of furosemide may significantly decrease nighttime frequency and percentage voided volume. [ taken 6 hrs before normal bedtime]
Although this approach is interesting and innovative, it is not likely to become a mainstay of treatment of lower urinary tract symptoms and clinical BPH.
It certainly presents a possible treatment option in men whose single most bothersome symptom is increased nighttime urination.