W Zimmerli for the Foreign-Body Infection (FBI) study group (Univ Hosps, Basel, Switzerland): Role of Rifampin for Treatment of Orthopedic Implant-related Staphylococcal Infections: A Randomized Controlled Trial.
Jama 279: 1537-1541, 1998.
Orthopaedic devices are frequently infected. They are associated with both high morbidity and cost. Based on animal model, a double-blind randomised placebo controlled clinical trial was conducted from 1992 through 1997 to assess the value of rifampin containing combination antibody therapy for patients with a stable orthopedic implant infected with staphylococci.
The clinical trial confirmed that with stable implants and short-term staphylococcal infections treated with initial debridement and long-term rifampin containing combination antibiotic therapy can be cured of their infection without removal of the device.