Speciality
Spotlight

   




 

Dermatology & Venereology

 

     




Genital
Warts

        

  • KR
    Beutner, SL Spruance, AJ
    Hougham, et al [ Univ of
    California, San Francisco;
    Sutter-Solano Med Ctr,
    Vallejo, Calif; Univ of Utah,
    Salt Lake City; et al]

    Treatment of Genital Warts
    With an Immune-response
    Modifier [Imiquimod]



    J Am Acad Dermatol 38:
    230-239, 1998


       

    The compound described in this
    article is a nonnucleoside
    heterocyclic amine [imiquimod]
    that in mice induces formation
    of tumor necrosis factor-(and
    interleukins 1,6 and 8.

       

    A 5% cream was applied to the
    affected areas thrice a week
    for a period of eight weeks.
    40% of the treated group
    cleared completely. The rest
    showed over 50% improvement.

       

    The importance of this study
    lies in indicating that
    immunomodulation may be a
    better way to treat tumors and
    warts than mechanical removal.

           

  • KR Beutner, SL Spruance, AJ Hougham, et al [ Univ of California, San Francisco; Sutter-Solano Med Ctr, Vallejo, Calif; Univ of Utah, Salt Lake City; et al]


    Treatment of Genital Warts With an Immune-response Modifier [Imiquimod]



    J Am Acad Dermatol 38: 230-239, 1998


      


    The compound described in this article is a nonnucleoside heterocyclic amine [imiquimod] that in mice induces formation of tumor necrosis factor-( and interleukins 1,6 and 8.

     


    A 5% cream was applied to the affected areas thrice a week for a period of eight weeks. 40% of the
    treated group cleared
    completely. The rest showed
    over 50% improvement.

     


    The importance of this study lies in indicating that immunomodulation may be a better way to treat tumors and warts than mechanical removal. 

      

  • Efficacy of treatment of syphilis in pregnancy.

    JM Alexander, et al
    (Univ of Texas, Dallas; Dallas
    County Health Dept, Dallas)

    Obstet
    Gynecol 93:5-8, 1999.


         

    Background:  
    Current guidelines for
    treating syphilis in pregnant
    women are based on research
    conducted in the 1940’s and
    1950’s which showed that a
    variety of penicillin based
    clinical regimens effectively
    prevent neonatal transmission
    of syphilis.

        

    Method: 
    Treatment was
    administered to 448 patients
    between 1987 and 1989. 
    It consisted of 2.4m
    units of IM benzathine
    penicillin G for primary,
    secondary or early latent
    syphilis.
    The late latent disease
    was treated with 7.2m units of
    IM benzathine penicillin G
    over 3 weeks.

        

    Conclusion: 
    Overall, the current
    centres for disease control
    recommendations for preventing
    congenital syphilis and for
    treating maternal infection
    are effective.
    The risk of fetal
    treatment failure is greatest
    in women with secondary
    syphilis.

       


    Editorial
    comments: Therapeutic failures
    occur in 5.3% of cases of
    maternal secondary syphilis
    and 2% of early (less than 1
    year duration) latent
    infection at the time of
    treatment.
    There is the need for
    primary treatment as early in
    pregnancy as possible to make
    re-treatment feasible and
    effective.

       




 

    

Speciality Spotlight

   

     

Genital Warts
        

  • KR Beutner, SL Spruance, AJ Hougham, et al [ Univ of California, San Francisco; Sutter-Solano Med Ctr, Vallejo, Calif; Univ of Utah, Salt Lake City; et al]
    Treatment of Genital Warts With an Immune-response Modifier [Imiquimod]
    J Am Acad Dermatol 38: 230-239, 1998
       
    The compound described in this article is a nonnucleoside heterocyclic amine [imiquimod] that in mice induces formation of tumor necrosis factor-(and interleukins 1,6 and 8.
       
    A 5% cream was applied to the affected areas thrice a week for a period of eight weeks. 40% of the treated group cleared completely. The rest showed over 50% improvement.
       
    The importance of this study lies in indicating that immunomodulation may be a better way to treat tumors and warts than mechanical removal.
           

  • KR Beutner, SL Spruance, AJ Hougham, et al [ Univ of California, San Francisco; Sutter-Solano Med Ctr, Vallejo, Calif; Univ of Utah, Salt Lake City; et al]
    Treatment of Genital Warts With an Immune-response Modifier [Imiquimod]
    J Am Acad Dermatol 38: 230-239, 1998
      
    The compound described in this article is a nonnucleoside heterocyclic amine [imiquimod] that in mice induces formation of tumor necrosis factor-( and interleukins 1,6 and 8.
     
    A 5% cream was applied to the affected areas thrice a week for a period of eight weeks. 40% of the treated group cleared completely. The rest showed over 50% improvement.
     
    The importance of this study lies in indicating that immunomodulation may be a better way to treat tumors and warts than mechanical removal. 
      

  • Efficacy of treatment of syphilis in pregnancy.
    JM Alexander, et al (Univ of Texas, Dallas; Dallas County Health Dept, Dallas)
    Obstet Gynecol 93:5-8, 1999.
         
    Background:   Current guidelines for treating syphilis in pregnant women are based on research conducted in the 1940’s and 1950’s which showed that a variety of penicillin based clinical regimens effectively prevent neonatal transmission of syphilis.
        
    Method:  Treatment was administered to 448 patients between 1987 and 1989.  It consisted of 2.4m units of IM benzathine penicillin G for primary, secondary or early latent syphilis. The late latent disease was treated with 7.2m units of IM benzathine penicillin G over 3 weeks.
        
    Conclusion:  Overall, the current centres for disease control recommendations for preventing congenital syphilis and for treating maternal infection are effective. The risk of fetal treatment failure is greatest in women with secondary syphilis.
       
    Editorial comments: Therapeutic failures occur in 5.3% of cases of maternal secondary syphilis and 2% of early (less than 1 year duration) latent infection at the time of treatment. There is the need for primary treatment as early in pregnancy as possible to make re-treatment feasible and effective.
       

 

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