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Speciality Spotlight
Wound Healing Keloids
- G. Richard Holt
1) Keloid Scars
2) Repair of damaged glottic mucosa.
Keloid scars have been and continue to be a challenging aspect of reconstructive surgery. New gene identity may help to understand molecular basis of the keloid, thus identifying those who are genetically susceptible.
At present use of Intralesional use of 5-Fluorouracil appears useful in good scar formation by suppressing fibroblastic activities, endothelial cell growth factor release,controlling angiogenesis.
Repair of damaged glottic mucosa may be aided by use of topical application of mitomycin-C as well as utilisation of hyaluronic acid. The normal mucosal return with the help of glottic to function better.
- Broker BJ, Chakrabarti R, Blynman T, et al (Univ of California Los Angeles)
Comparison of Growth Factor Expression in Fetal and Adult Fibroblasts: A Preliminary Report.
Arch Otolaryngol Head Neck Surg 125: 676-680, 1999
The factors in healing wounds by fibroblasts were studied in vitro. Fetal has scarless healing against adult scars.
It was found that adult fibroblasts have a relative excess of cytokine production compared to fetal fibroblasts. This excess may contribute to poor wound healing in adults. Such studies in parallel with human genome project may determine not only the molecular basis of scar formation but also genetic predisposition to excessive scarring. Under the influence of human growth factor, fibroblasts appear to be the conveyor of wound healing.
