Ed- Morley John E.-Year Book of Endocrinology 1999
The free radical theory of aging remains one of the pre-eminent theories of aging. Oxidative damage from reactive oxygen species (free radicals) has been implicated not only in aging but also in age related diseases such as cancer, atherosclerosis and even Alzheimer’s disease.
The major competing theory to the free radical theory of aging is the genetic theory.
A survey showed that diabetes occurred in 20.2% of men and 17.8% of women aged 60 to 74 years with even higher figures in older men and women. The risk of mortality in diabetes aged 65 to 75 years is 1.5 times the risk of mortality in general. It also showed that diabetic control decreased microvascular complications and treating hypertension in diabetic patients is at least as important as treating diabetes itself. In obese diabetic patients, metformin stood out as the drug of choice.