Speciality
Spotlight

 




 


Endocrinology


   

  




Critical
Medicine

    

  • Lena
    Gamrin, Pia Essen, Eric Hultman, et al (The Department
    of Anesthesiology and Intensive Care and Clinical
    Chemistry II, Huddinge University Hospital, Karolinska
    Institute, Stockholm, Sweden; and the Department of
    Surgery at State University of New York,Stony Brook,
    New York)

    Protein-Sparing
    Effect in Skeletal Muscle of Growth Hormone Treatment
    in Critically III Patients.

    Annals of Surgery, April 2000, 231(4), 577-586.

       

    This study investigates the effect of growth
    hormone (GH) treatment on skeletal muscle protein
    catabolism in patients with multiple organ failure in
    the ICU.

       

    20
    critically ill ICU patients were randomized into 2
    groups – one as control and the other with GH
    (0.3U/kg/day). Percutaneous muscle biopsy was taken
    before and 5 days after treatment starting on day 3 to
    42 of the patient’s ICU stay. 
    Protein content, protein synthesis, water
    nucleic acids and free amino acids were analysed.

      

    The
    fractional protein synthesis rate and muscle free
    glutaminic increased in 
    the GH group. 
    Total intramuscular water did not increase but
    the intracellular water increased.

       

    It
    is concluded that treatment with GH in patients with
    multiple organ failure, stimulated muscle protein
    synthesis, increased muscle free glutaminic and
    increased into a cellular water.

       

 



 

 

Speciality Spotlight

 

 
Endocrinology
   

  

Critical Medicine
    

  • Lena Gamrin, Pia Essen, Eric Hultman, et al (The Department of Anesthesiology and Intensive Care and Clinical Chemistry II, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden; and the Department of Surgery at State University of New York,Stony Brook, New York)
    Protein-Sparing Effect in Skeletal Muscle of Growth Hormone Treatment in Critically III Patients.
    Annals of Surgery, April 2000, 231(4), 577-586.
       
    This study investigates the effect of growth hormone (GH) treatment on skeletal muscle protein catabolism in patients with multiple organ failure in the ICU.
       
    20 critically ill ICU patients were randomized into 2 groups – one as control and the other with GH (0.3U/kg/day). Percutaneous muscle biopsy was taken before and 5 days after treatment starting on day 3 to 42 of the patient’s ICU stay.  Protein content, protein synthesis, water nucleic acids and free amino acids were analysed.
      
    The fractional protein synthesis rate and muscle free glutaminic increased in  the GH group.  Total intramuscular water did not increase but the intracellular water increased.
       
    It is concluded that treatment with GH in patients with multiple organ failure, stimulated muscle protein synthesis, increased muscle free glutaminic and increased into a cellular water.
       

 

 

By |2022-07-20T16:41:29+00:00July 20, 2022|Uncategorized|Comments Off on Critical Medicine

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