Vascular Surgery

Vascular
Surgery

   

• D.R.
  Chadwick, B.J. Harrison, P. Chan*, 
  L. Chong and P. Peachell [ Departments of
  Endocrine Surgery and *Vascular Surgery, Northern
  General Hospital 
  and Section of Molecular Pharmacology and
  Pharmacogenetics, University of Sheffield Royal
  Hallamshire Hospital, Sheffield, UK]
  
  Vasoactive
  and Proliferative Effects of Parathyroid Hormone and
  Parathyroid Hormone-Related Peptide on Human Vascular
  Smooth Muscle
  
  Br.
  Jour. of  Sur.
  Volume 87, No.11, November 2000, Pgs- 1529-1533
  
   
  
  Hyperparathyroidism
  is associated with an increased incidence of
  hypertension and cardiovascular disease. This probably
  results from desensitization of the normally
  inhibitory effects of parathyroid hormone-related
  peptide [PTHrP] on vascular smooth muscle cells [VSMCs]
  by previous exposure to parathyroid hormone [PTH].
  
   
  
  Isometric
  tension in vitro was measured in segments of vessels
  obtained at neck surgery from six normotensive
  patients with hyperparathyroidism and 12 eucalcaemic
  controls. Vessels were precontracted with
  noradrenaline to allow the vasodilatory effects of PTH
  and PTHrP.
  
   
  
  Human
  VSMCs were cultured in 0.5%, 5% and 15% serum with or
  without PTH, and proliferation was assessed by cell
  counts after 14 days.
  
   
  
  There
  was no difference in the results obtained between
  controls and hyperparathyroidism groups.
  
   
  
  This
  data implies that homologous desensitization to PTHrP
  is not implicated in the pathogenesis of vascular
  disease in patients with hyperparathyroidism.