Speciality
Spotlight

 




 


Endocrinology


   

  




weight
Loss

  


 



   
A
significant weight loss is usually a marker of
serious Disease. 
Even if no underlying cause is found on
initial evaluation it does not mean that weight
loss is idiopathic.
The patient should be followed at regular
intervals, since any occult illness causing weight
loss may not be found for long periods.

  

Diagnosis
of the cause of weight loss is usually not difficult
and is revealed by history, physical examination
and
routine laboratory screening.

The
most likely causes:

  

    
In
young persons
:

  • diabetes
    mellitus

  • hyperthyroidism

  • anorexia
    nervosa

  • HIV
    infection

    
In
elderly persons:

  • Cancer

  • Alzheimer’s
    disease

  • Depression

       




 weight
Loss Causes

    

Increased
Energy
Expenditure

  • Hyperthyroidism

  • Pheochromocytoma

  • Extensive
    exercise

Increased
Energy
Loss

Diabetes
Mellitus
(Glucose
in Urine)

 

Malabsorption syndromes:

  • Radiation
    Injury.

  • Biliary
    Tract Obstruction.

  • Inflammatory
    bowel dis
    ease.
    e.g.- Ulcerative Colitis.

  • Chronic
    Pancreatitis in alcoholics.

        

Decreased
Food
Intake

  • Infection
    (HIV, Tuberculosis

    and  
    endocarditis)

  • Obstruction
    of G.I. Tract.

  • Anorexia
    nervosa

  • Cancer


  • Depression

  • Alzheimer’s
    disease.




   


Weight
Loss : Diagnosis

   

First
Phase
Tests

These
tests are done on every patient.

  • Multiple
    chemistry tests
    (To detect diabetes mellitus, renal failure, liver disease, or
    gastrointestinal disease)

  • T.S.H.
    (for hyperthyroidism)

  • HIV
    test

  • Chest
    X-ray

  • Stool
    test for occult blood

  • C.B.C.

  • E.S.R.

  • Urine
    test.

Second
Phase
Tests

These
tests are done only if the first phase tests are
unable to detect the cause of weight loss.

  • C.T.
    Scan of abdomen

  • Serum
    parathyroid hormone (PTH)

  • Mammography

  • ACTH
    test

  • Upper
    G.I. Endoscopy

  • Colonoscopy

  • Blood
    culture (for fever with weight loss)

  • 72
    hr stool fat (in presence of chronic diarrhoea)

  • MRI
    (for weight loss with neurological symptoms)

  • Vitamin
    B12 levels (in unexplained weight
    loss)

       

 

 



 

 

Speciality Spotlight

 

 
Endocrinology
   

  

weight Loss
  

 

    A significant weight loss is usually a marker of serious Disease.  Even if no underlying cause is found on initial evaluation it does not mean that weight loss is idiopathic. The patient should be followed at regular intervals, since any occult illness causing weight loss may not be found for long periods.
  
Diagnosis of the cause of weight loss is usually not difficult and is revealed by history, physical examination and routine laboratory screening.

The most likely causes:
  
     In young persons:

  • diabetes mellitus

  • hyperthyroidism

  • anorexia nervosa

  • HIV infection

     In elderly persons:

  • Cancer

  • Alzheimer’s disease

  • Depression
       

 weight Loss Causes
    

Increased Energy Expenditure

  • Hyperthyroidism

  • Pheochromocytoma

  • Extensive exercise

Increased Energy Loss

Diabetes Mellitus (Glucose in Urine)
 
Malabsorption syndromes:

  • Radiation Injury.

  • Biliary Tract Obstruction.

  • Inflammatory bowel disease. e.g.- Ulcerative Colitis.

  • Chronic Pancreatitis in alcoholics.
        

Decreased Food Intake

  • Infection (HIV, Tuberculosis and   endocarditis)

  • Obstruction of G.I. Tract.

  • Anorexia nervosa

  • Cancer

  • Depression

  • Alzheimer’s disease.

   
Weight Loss : Diagnosis
   

First Phase Tests

These tests are done on every patient.

  • Multiple chemistry tests (To detect diabetes mellitus, renal failure, liver disease, or gastrointestinal disease)

  • T.S.H. (for hyperthyroidism)

  • HIV test

  • Chest X-ray

  • Stool test for occult blood

  • C.B.C.

  • E.S.R.

  • Urine test.

Second Phase Tests

These tests are done only if the first phase tests are unable to detect the cause of weight loss.

  • C.T. Scan of abdomen

  • Serum parathyroid hormone (PTH)

  • Mammography

  • ACTH test

  • Upper G.I. Endoscopy

  • Colonoscopy

  • Blood culture (for fever with weight loss)

  • 72 hr stool fat (in presence of chronic diarrhoea)

  • MRI (for weight loss with neurological symptoms)

  • Vitamin B12 levels (in unexplained weight loss)
       

 

 

 

By |2022-07-20T16:41:59+00:00July 20, 2022|Uncategorized|Comments Off on Weight Loss

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