RB Jones, and the Trovafloxacin Gonorrhea Study Group [Indiana Univ; Indianapolis; Univ of Alabama, Birmingham; Memphis Womens Ctr, Tenn; et al]
Randomized Trial of Trovafloxacin and Ofloxacin for Single-Dose Therapy of Gonorrhea
Am J Med 104 : 28-32, 1998
Study comprised 625 women and men, suffering from gonococcal infection of the cervix and or urethra in the former and urethritis in the latter.
A single dose of 400 mgm of ofloxacin was curative in 98% of the subjects and results with trovafloxacin in a dose of 100 mgm were 99%. Both agents therefore are effective.
- Genital Warts
KR Beutner, SL Spruance, AJ Hougham, et al [ Univ of California, San Francisco; Sutter-Solano Med Ctr, Vallejo, Calif; Univ of Utah, Salt Lake City; et al]
Treatment of Genital Warts With an Immune-response Modifier [Imiquimod]
J Am Acad Dermatol 38: 230-239, 1998
The compound described in this article is a nonnucleoside heterocyclic amine [imiquimod] that in mice induces formation of tumor necrosis factor-( and interleukins 1,6 and 8.
A 5% cream was applied to the affected areas thrice a week for a period of eight weeks. 40% of the treated group cleared completely. The rest showed over 50% improvement.
The importance of this study lies in indicating that immunomodulation may be a better way to treat tumors and warts than mechanical removal.