Speciality
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Genetics


    

 





Otosclerosis

    

  • Singhal SK, Mann SBS, Datta U, et al (Postgraduate Inst of Medical Education and Research, Chandigarh, India)


    Genetic Correlation in Otosclerosis



    Am J Otolaryngol 20: 102-105, 1999


       

    Otosclerosis is inherited in an autosomal-dominant manner and some authors have suggested association between this disease and ABO blood groups.

       

    100 patients of otosclerosis and 100 normal controls matched for age and sex underwent Human Leukocyte antigen (HLA) typing. The frequencies of the HLA antigens were then compared. Otosclerotic patients have significantly higher levels of HLA-A3, HLA-A9, HLA-A11 and HLA-B13 than controls. This suggested strongly HLA related component to the disease. Further HLA-A9 and HLA-A11 levels in patients with family history suggests genetic heterogenicity. Why HLA-A3 levels were significantly higher in females than males remain unknown.

       

    Otosclerotic, a genetic disease was always known. The authors and others are finding more specific ways in which genetic factors play a role. This is significant finding and such continued studies will shed more light.

        

 



 

 

Speciality Spotlight

 

 
Genetics
    

 

Otosclerosis
    

  • Singhal SK, Mann SBS, Datta U, et al (Postgraduate Inst of Medical Education and Research, Chandigarh, India)
    Genetic Correlation in Otosclerosis
    Am J Otolaryngol 20: 102-105, 1999
       
    Otosclerosis is inherited in an autosomal-dominant manner and some authors have suggested association between this disease and ABO blood groups.
       
    100 patients of otosclerosis and 100 normal controls matched for age and sex underwent Human Leukocyte antigen (HLA) typing. The frequencies of the HLA antigens were then compared. Otosclerotic patients have significantly higher levels of HLA-A3, HLA-A9, HLA-A11 and HLA-B13 than controls. This suggested strongly HLA related component to the disease. Further HLA-A9 and HLA-A11 levels in patients with family history suggests genetic heterogenicity. Why HLA-A3 levels were significantly higher in females than males remain unknown.
       
    Otosclerotic, a genetic disease was always known. The authors and others are finding more specific ways in which genetic factors play a role. This is significant finding and such continued studies will shed more light.
        

 

 

By |2022-07-20T16:41:26+00:00July 20, 2022|Uncategorized|Comments Off on Otosclerosis

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