Speciality
Spotlight

 




 


Immunology


 

 




Drug
Assistance in HIV

         

  • Little
    SJ, Daar ES, D’Acquila RT, et al [ Univ of
    California, San Diego; Univ of California, Los
    Angeles; Massachusetts Gen Hosp, Boston; et al]

    Reduced Antiretroviral Drug Susceptibility Among
    Patients with Primary HIV Infection


    JAMA 282: 1142-1149, 1999

        

    It is not known how often HIV resistant to one or
    more antiretroviral [ARV] drugs causes new
    infections.

        

    Acute and early infections in subjects were studied
    between the years 1989 and 1998. Plasma samples were
    taken from 141 such cases in 5 different centres.
    Drug effect on the virus were studied. A 2.5 times
    reduction of effect was the standard used. Five
    samples showed reduction in more than this level to
    at least 1 nucleoside reverse transcriptase
    inhibitor [NRTI], 2 revealed 10 times reduction and
    24 samples to a non-NRTI . Only 1 showed a 10 >
    times reduction. A single mutation in the resistant
    group T215Y was discovered in 36 samples.

       

    In HIV infections resistance 2.5 and 10 times range
    are common. Testing for resistant virus strains is
    advised in areas of high prevalence of
    uncontrollable AIDS.

 



 

 

Speciality Spotlight

 

 

Drug Assistance in HIV
         

  • Little SJ, Daar ES, D’Acquila RT, et al [ Univ of California, San Diego; Univ of California, Los Angeles; Massachusetts Gen Hosp, Boston; et al]
    Reduced Antiretroviral Drug Susceptibility Among Patients with Primary HIV Infection
    JAMA 282: 1142-1149, 1999
        
    It is not known how often HIV resistant to one or more antiretroviral [ARV] drugs causes new infections.
        
    Acute and early infections in subjects were studied between the years 1989 and 1998. Plasma samples were taken from 141 such cases in 5 different centres. Drug effect on the virus were studied. A 2.5 times reduction of effect was the standard used. Five samples showed reduction in more than this level to at least 1 nucleoside reverse transcriptase inhibitor [NRTI], 2 revealed 10 times reduction and 24 samples to a non-NRTI . Only 1 showed a 10 > times reduction. A single mutation in the resistant group T215Y was discovered in 36 samples.
       
    In HIV infections resistance 2.5 and 10 times range are common. Testing for resistant virus strains is advised in areas of high prevalence of uncontrollable AIDS.

 

 

By |2022-07-20T16:42:11+00:00July 20, 2022|Uncategorized|Comments Off on Drug Assistance in HIV

About the Author: