Drug Assistance in HIV

Drug
Assistance in HIV

         

• Little
  SJ, Daar ES, D’Acquila RT, et al [ Univ of
  California, San Diego; Univ of California, Los
  Angeles; Massachusetts Gen Hosp, Boston; et al]
  
  Reduced Antiretroviral Drug Susceptibility Among
  Patients with Primary HIV Infection
  
  JAMA 282: 1142-1149, 1999
  
      
  
  It is not known how often HIV resistant to one or
  more antiretroviral [ARV] drugs causes new
  infections.
  
      
  
  Acute and early infections in subjects were studied
  between the years 1989 and 1998. Plasma samples were
  taken from 141 such cases in 5 different centres.
  Drug effect on the virus were studied. A 2.5 times
  reduction of effect was the standard used. Five
  samples showed reduction in more than this level to
  at least 1 nucleoside reverse transcriptase
  inhibitor [NRTI], 2 revealed 10 times reduction and
  24 samples to a non-NRTI . Only 1 showed a 10 >
  times reduction. A single mutation in the resistant
  group T215Y was discovered in 36 samples.
  
     
  
  In HIV infections resistance 2.5 and 10 times range
  are common. Testing for resistant virus strains is
  advised in areas of high prevalence of
  uncontrollable AIDS.