Assistance in HIV
SJ, Daar ES, D’Acquila RT, et al [ Univ of
California, San Diego; Univ of California, Los
Angeles; Massachusetts Gen Hosp, Boston; et al]
Reduced Antiretroviral Drug Susceptibility Among Patients with Primary HIV Infection
JAMA 282: 1142-1149, 1999
It is not known how often HIV resistant to one or more antiretroviral [ARV] drugs causes new infections.
Acute and early infections in subjects were studied between the years 1989 and 1998. Plasma samples were taken from 141 such cases in 5 different centres. Drug effect on the virus were studied. A 2.5 times reduction of effect was the standard used. Five samples showed reduction in more than this level to at least 1 nucleoside reverse transcriptase inhibitor [NRTI], 2 revealed 10 times reduction and 24 samples to a non-NRTI . Only 1 showed a 10 > times reduction. A single mutation in the resistant group T215Y was discovered in 36 samples.
In HIV infections resistance 2.5 and 10 times range are common. Testing for resistant virus strains is advised in areas of high prevalence of uncontrollable AIDS.