Speciality
Spotlight

 




 


Prevention of HIV Infection


 

 



  • Eckert
    DM, Malashkevich VN, Hong LH, et al [ Howard Hughes
    Med Inst, Cambridge, Mass]

    Inhibiting HIV-1 Entry: Discovery of D-Peptide
    Inhibitors That Target the gp41 Coiled-Coil Pocket


    Cell 99 : 103-115, 1999

      

    Prevention of HIV-1 virus from entering a cell seems
    logical. Short chains of D-amino acids resistant to
    proteolysis and designated 1QN17 act by attaching to
    the gp41 region of the virus. These newly discovered
    chains thus prevent the virus from using such
    proteins on the cell membrane of the host. It is of
    interest that the agent can be given by mouth as a
    tablet.

       
  • Hazuda
    DJ, Felock P, Witmer M, et al [Merck Research Labs,
    West Point, Pa]

    Inhibitors of Strand Transfer That Prevent
    Integration and Inhibit HIV-1 Replication in Cells


    Science 287: 646-650, 2000

      

    In the management of HIV-1 infection drugs acting on
    reverse transcriptase and protease enzymes of the
    virus have been relied upon. The development of
    resistance constitutes an important reason for
    search of alternatives.

       

    HIV integrase is used by the virus to allow its DNA
    to be introduced into the cell genome, a step
    necessary for it to replicate. This article
    introduces diketo acids L-731,988 and L-708,906 to
    prevent such strand integration.

       

    At the moment it is in the experimental stage.  

 



 

 

Speciality Spotlight

 

 

  • Eckert DM, Malashkevich VN, Hong LH, et al [ Howard Hughes Med Inst, Cambridge, Mass]
    Inhibiting HIV-1 Entry: Discovery of D-Peptide Inhibitors That Target the gp41 Coiled-Coil Pocket
    Cell 99 : 103-115, 1999
      
    Prevention of HIV-1 virus from entering a cell seems logical. Short chains of D-amino acids resistant to proteolysis and designated 1QN17 act by attaching to the gp41 region of the virus. These newly discovered chains thus prevent the virus from using such proteins on the cell membrane of the host. It is of interest that the agent can be given by mouth as a tablet.
       
  • Hazuda DJ, Felock P, Witmer M, et al [Merck Research Labs, West Point, Pa]
    Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells
    Science 287: 646-650, 2000
      
    In the management of HIV-1 infection drugs acting on reverse transcriptase and protease enzymes of the virus have been relied upon. The development of resistance constitutes an important reason for search of alternatives.
       
    HIV integrase is used by the virus to allow its DNA to be introduced into the cell genome, a step necessary for it to replicate. This article introduces diketo acids L-731,988 and L-708,906 to prevent such strand integration.
       
    At the moment it is in the experimental stage.  

 

 

By |2022-07-20T16:41:29+00:00July 20, 2022|Uncategorized|Comments Off on Prevention HIV

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