Speciality
Spotlight

 




 


Immunology


 

 




Immunoglobulin

     

  • Hofstra CL, Van Ark, I, Hofman G, et al [Utrecht Univ, The Netherlands]

    Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 is Associated with Inhibition of Antigen-induced Airway hyperresponsiveness, Eosinophilia, and Serum IgE Levels

    J Immunol 161: 5054-5060, 1998

       

    Inhibiting the T-helper (TH) 2-cell response may prove a promising means of intervention in allergic asthma and any other allergic disorders.

       

    The authors in the current study have used a standard model of immunizing the mice with Ova followed by serial OVA inhalational challenges. This readily induces allergen-specific IgE, airway hyperreactivity, and airway inflammation characterised predominantly by eosinophils. The study demonstrates the synergistic ability of IL-12 and IL-18 together as asthma-like inflammation. However, each cytokine can be given at a dose which, by itself, may be sufficient to suppress TH2-like differentiation without inducing cellular inflammatory responses in the lung. The risk therefore a slight inclination in the data that IL-12 alone may actually enhance airway eosinophilia and IL-5 production without, by itself, modulating IgE or other cytokines. It is only in the combination with IL-18 that the maximal anti-inflammatory effects are observed. This has obvious implications for human asthma for which trials with inhaled IL-12 are already underway, after the previous idea of using systemic IL-12 was discontinued.

        

  • RA Erger, TB Casale, (Univ of Iowa, Iowa City; Nebraska Med Research Inst, Papillion)

    Interleukin-8 Plays a Significant Role in IgE-mediated Lung Inflammation.

    Eur Respir J 11:299-305, 1998

      

    In the article, IL-8 which is an important chemokine is thought to be more associated with neutrophil activation as opposed to eosinophil activation, is examined for its contribution to anti-IgE-treated induction of neutrophil and eosinophil migration, using lung samples taken from humans. The human lung IgE-mediated response in vitro has been shown to be dependent on IL-8 and IL-8 which is an important biological modifier in the induction and generation of granulocyte transcellular migration. 

       

    The recent findings that neutrophils may again resurrect a significant role in the inflammation in asthma, especially in the more potentially severe and fatal asthma, suggests that an understanding of its potential mechanism of induction of cellular accumulation and lung inflammation in asthma may be important, though indirect contributor to airway hyperresponsiveness. More importantly it may also be an indicator or marker of either fatal or severe asthma.

        

 



 

 

Speciality Spotlight

 

 

Immunoglobulin
     

  • Hofstra CL, Van Ark, I, Hofman G, et al [Utrecht Univ, The Netherlands]
    Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 is Associated with Inhibition of Antigen-induced Airway hyperresponsiveness, Eosinophilia, and Serum IgE Levels
    J Immunol 161: 5054-5060, 1998
       
    Inhibiting the T-helper (TH) 2-cell response may prove a promising means of intervention in allergic asthma and any other allergic disorders.
       
    The authors in the current study have used a standard model of immunizing the mice with Ova followed by serial OVA inhalational challenges. This readily induces allergen-specific IgE, airway hyperreactivity, and airway inflammation characterised predominantly by eosinophils. The study demonstrates the synergistic ability of IL-12 and IL-18 together as asthma-like inflammation. However, each cytokine can be given at a dose which, by itself, may be sufficient to suppress TH2-like differentiation without inducing cellular inflammatory responses in the lung. The risk therefore a slight inclination in the data that IL-12 alone may actually enhance airway eosinophilia and IL-5 production without, by itself, modulating IgE or other cytokines. It is only in the combination with IL-18 that the maximal anti-inflammatory effects are observed. This has obvious implications for human asthma for which trials with inhaled IL-12 are already underway, after the previous idea of using systemic IL-12 was discontinued.
        

  • RA Erger, TB Casale, (Univ of Iowa, Iowa City; Nebraska Med Research Inst, Papillion)
    Interleukin-8 Plays a Significant Role in IgE-mediated Lung Inflammation.
    Eur Respir J 11:299-305, 1998
      
    In the article, IL-8 which is an important chemokine is thought to be more associated with neutrophil activation as opposed to eosinophil activation, is examined for its contribution to anti-IgE-treated induction of neutrophil and eosinophil migration, using lung samples taken from humans. The human lung IgE-mediated response in vitro has been shown to be dependent on IL-8 and IL-8 which is an important biological modifier in the induction and generation of granulocyte transcellular migration. 
       
    The recent findings that neutrophils may again resurrect a significant role in the inflammation in asthma, especially in the more potentially severe and fatal asthma, suggests that an understanding of its potential mechanism of induction of cellular accumulation and lung inflammation in asthma may be important, though indirect contributor to airway hyperresponsiveness. More importantly it may also be an indicator or marker of either fatal or severe asthma.
        

 

 

By |2022-07-20T16:41:28+00:00July 20, 2022|Uncategorized|Comments Off on Immunoglobulin

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