RO Darouiche, for the Catheter Study Group (Baylor College of Medicine, Houston; et al)
A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters.
N Engl J Med 340: 1-8, 1999.
A study of 2611 catheters (central venous) showed that impregnation with chlorhexidine and silver sulfadiazine reduced the incidence of catheter colonization and catheter associated bloodstream infections.
A direct comparison was made between catheter associated infections using minocycline/rifampin or chlorhexidine/silver sulfadiazine impregnated catheters. A central venous catheter kept for more than 3 days, the catheter colonization rate was 8.3% in the minocycline/rifampin group as compared to 22.8% in the chlorhexidine/silver sulfadiazine group. Both impregnated groups were better than non-impregnated catheters.
But to note that the minocycline/rifampin catheters were impregnated both externally and internally as compared to chlorhexidine/silver sulfadiazine catheters, which were coated only externally.
F Blot, E Schmidt, G Nitenberg, et al (Institute Gustave Roussy, Villejuif, France; Unversite Paris XI) :
Earlier positivity of Central-Venous-Versus Peripheral-Blood Cultures is Highly Predictive of Catheter-Related Sepsis.
J Clin Microbiol 36: 105-109, 1998.
Central venous catheter (CVC) related infection usually requires removal of the catheter. A comparison of the material obtained form the catheter tip and cultures of blood drawn simultaneously showed that this may be a reliable method for diagnosis of catheter related sepsis with indwelling catheters.