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Medicine


   

 




Cholesterol

  

  • Roberto
    Menendez, Rosa Mas, Ana MA, et al ( Center
    of Natural Products, National Center for scientific
    Research, Cuba).

    Effects of policosanol treatment on the
    susceptibility of low density lipoprotein (LDL)
    isolated from healthy volunteers to oxidative
    modification in vitro
    .



    Br. J.Cl.Pharmacol, Sept.2000; 50(3): 255-262.


     


    Summary:
    Policosanol is a mixture of higher primary aliphatic
    alcohols from sugar cane wax with cholesterol
    lowering effects, demonstrated in animal models,
    healthy volunteers and patients with type II
    hypercholesterolaemia. Oxidation of LDL cholesterol provides a link between plasma
    LDL-C and development of atherosclerosis.
    Oxidised LDL-C is taken up by macrophages
    leading to lipid filled foam cells- hall mark of
    atherosclerotic lesions.

      

    Effects of
    5 and 10mg/day policosanol on LDL-C oxidation was
    studied in double-blind, randomised,
    placebo-controlled trial in 69 subjects. LDL-C samples were isolated at baseline and after 8 weeks and
    were subjected to in-vitro tests of LDL-C oxidation.

         

    The
    study showed that policosanol administered within
    its therapeutic range, decreased susceptibility of
    LDL-C to lipid-peroxidation in vitro. Since policosanol is a cholesterol-lowering
    agent, additional anti1oxidant effect may contribute
    to reduction of atherosclerosis.

                         

 



 

           

Speciality Spotlight

       

 
Medicine
   

 

Cholesterol
  

  • Roberto Menendez, Rosa Mas, Ana MA, et al ( Center of Natural Products, National Center for scientific Research, Cuba).
    Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro.
    Br. J.Cl.Pharmacol, Sept.2000; 50(3): 255-262.
     
    Summary: Policosanol is a mixture of higher primary aliphatic alcohols from sugar cane wax with cholesterol lowering effects, demonstrated in animal models, healthy volunteers and patients with type II hypercholesterolaemia. Oxidation of LDL cholesterol provides a link between plasma LDL-C and development of atherosclerosis. Oxidised LDL-C is taken up by macrophages leading to lipid filled foam cells- hall mark of atherosclerotic lesions.
      
    Effects of 5 and 10mg/day policosanol on LDL-C oxidation was studied in double-blind, randomised, placebo-controlled trial in 69 subjects. LDL-C samples were isolated at baseline and after 8 weeks and were subjected to in-vitro tests of LDL-C oxidation.
         
    The study showed that policosanol administered within its therapeutic range, decreased susceptibility of LDL-C to lipid-peroxidation in vitro. Since policosanol is a cholesterol-lowering agent, additional anti1oxidant effect may contribute to reduction of atherosclerosis.
                         

 

 

By |2022-07-20T16:42:07+00:00July 20, 2022|Uncategorized|Comments Off on Cholesterol

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