E Marchand, and the Groupe d”Etudes et de Recherche sur les Maladies “Orphelines” Pulmonaries (GERM “O”P) (Hopital Cardiovasculaire et Pneumologique Louis Pradel, Lyon, France; et al).
Idiopathic Chronic Eosinophilic Pneumonia: A Clinical and Follow-up Study of 62 cases.
Medicine 77:299-312, 1998.
Idiopathic chronic eosinophilic pneumonia (CEP), a rare disorder of unknown causes.
Of 62 carefully selected patients with CEP, 46 were followed up for more than 1 year. All patients had bronchoalveolar lavage (BAL) eosinophilia. Sixty-eight percent of the patients had a ventilatory defect, which was obstructive in 35% and restrictive in 32%. Open lung biopsy was performed in only 6.5% of the patients.
All but 1 patient received oral corticosteroid therapy, at a mean initial dose of 0.97mg/kg per day of prednisone. All treated patients had rapid subjective improvement. Eighty-two percent were improved within 48 hours. Within 1 week of treatment, 49 patients underwent chest radiography, which showed disappearance of initial opacities in 69.4%. Forty-eight relapses occurred in 30 (48%) patients.