EK Hoogeveen, PJ Kostense., A Jager, et al (Vrije Universiteit, Amsterdam)
Serum Homocysteine Level and Protein Intake Are Related to Risk of Microalbuminuria: The Hoorn Study.
Kidney Int 54: 203-209, 1998.
Both hyperhomocysteinemia and protein intake are associated with increased risk of Microalbuminuria (MA), independent of non-insulin-dependent diabetes mellitus, hypertension, or other known risk factors. Hyperhomocysteinemia may be part of the link between MA and cardiovascular disease.
AG Bostom, RY Gohh, AJ Beaulieu, et al (Jean Mayer USDA Human Nutrition research Ctr, Boston; Rhode Island Hosp, Providence; Mem Hosp of Rhode Island, Pawtucket)
Treatment of Hyperhomocysteinemia in Renal Transplant Recipients: A Randomized, Placebo controlled trial.
Ann Intern Med 127:1089-1092, 1997.
It is of interest that plasma homocysteine increases in renal transplant recipients even in the presence of slight renal impairment. This may contribute to an increased risk of cardiovascular disease in these individuals.
Administration of vitamin B6 decreased homocysteine by 22% and folic acid plus vitamin B12 decreased homocysteine by 26%.