F Nosten, M van Vugt, et al (Department of Infectious Diseases, Tropical Medicine and AIDS, Amsterdam, Netherlands)
Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in Western Thailand: a prospective study.
Lancet, vol.356, July 22, 2000, p. 297-302.
Morbidity and mortality from lasmodium falciparum malaria is increasing in tropical areas. This increase results partly from the spread of drug resistance.
In this area of Thailand, early diagnosis and treatment with combined artesunate and mefloquine has reduced the incidence of plasmodium falciparum malaria and halted progression of mefloquine resistance.Authors recommend that antimalarial drugs should be combined with artemisinin or a derivative to protect them against resistance.