Ronald J Falk, (University of North Carolina, Chapel Hill)
Treatment of Lupus Nephritis – At work in progress
N Engl J Med 2000; 343(16), 19 October 2000, pg.1182-83
Treatment of lupus nephritis is unsatisfactory and the result with the standard immunosuppresive agent is not very good. Addition of corticosteroids to standard immunosuppressive drugs introduced its own adverse reaction, especially, since treatment has to be continued life-long.
A new immunosuppressive agent, mycophenolate mofetil has been tried for many severe autoimmune diseases with good results. Treatment with mycophenolate mofetil in lupus nephritis improves the outcome, both with regard to life as well as progression of the disease.