A Freifeld, D Marchigiani, T Walshi, et al (NIH, Bethesda, Md; Univ of South Florida, Tampa; Harvard Med School, Boston)
A Double-blind Comparison of Empirical Oral and Intravenous Antibiotic Therapy for Low-risk Febrile Patients with Neutropenia During Cancer Chemotherapy.
N Engl J Med 341: 305-311, 1999.
Patients with fever and neutropenia during cancer chemotherapy are usually treated by parenteral antibiotics. This study demonstrated that oral ciprofloxacin and amoxycillin is as good parenteral antibiotics.
WV Kern, for the International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatmetn of Cancer (Medizinische Universitatsklinik und Poliklinik, Ulm, Germany)
Oral Versus Intravenous Empirical Antibmicrobial Therapy for Fever In Patients with Granulocytopenia who are Receiving Cancer Chemotherapy.
N Engl J Med 341: 312-318, 1999.
Low risk patients with fever and granulocytopenia due to cancer chemotherapy can be effectively treated with oral ciprofloxacin and amoxycillin instead of parenteral antibiotics. This improves the quality of life.