Proton Pump Inhibitors

Proton
Pump Inhibitors

    

• R.M.
  Martin, N. R Dunn, et al (University
  of Bristol, Department of Social Medicine, Bristol
  and Drug Safety Research Unit, Southampton)
  
  The
  rates of common adverse events reported during
  treatment with proton pump inhibitors used in
  general practice in England: cohort studies.
  
  Br.J.Cl.Pharmacol,
  Oct.2000; 50(4), 366-372
  
    
  
  Summary:
  The aim of this study was to estimate the rates of
  common adverse events in patients treated with the
  proton pump inhibitors-omeprazole, lansoprazole and
  pantoprazole, in general practice in England.
  
   
  
  In
  this prescription event monitoring study, data on
  prescriptions prescribed by GPs in England soon
  after each drug was launched, were linked to
  subsequent clinical events recorded by the
  prescriber. The
  number of patients were, 16205 for omeprazole, 17329
  for lansoprazole and 11541 for pantoprazole.
  
         
  
  The
  common adverse events were diarrhoea,
  nausea/vomiting, abdominal pain and headache. 
  Adverse events occurred relatively
  infrequently in all 3 groups. There were only small absolute differences in
  event rates between the 3 drugs, although these data
  suggest that lansoprazole is associated with more
  frequent occurrence of diarrhoea particularly in the
  elderly.