R.M. Martin, N. R Dunn, et al (University of Bristol, Department of Social Medicine, Bristol and Drug Safety Research Unit, Southampton)
The rates of common adverse events reported during treatment with proton pump inhibitors used in general practice in England: cohort studies.
Br.J.Cl.Pharmacol, Oct.2000; 50(4), 366-372
Summary: The aim of this study was to estimate the rates of common adverse events in patients treated with the proton pump inhibitors-omeprazole, lansoprazole and pantoprazole, in general practice in England.
In this prescription event monitoring study, data on prescriptions prescribed by GPs in England soon after each drug was launched, were linked to subsequent clinical events recorded by the prescriber. The number of patients were, 16205 for omeprazole, 17329 for lansoprazole and 11541 for pantoprazole.
The common adverse events were diarrhoea, nausea/vomiting, abdominal pain and headache. Adverse events occurred relatively infrequently in all 3 groups. There were only small absolute differences in event rates between the 3 drugs, although these data suggest that lansoprazole is associated with more frequent occurrence of diarrhoea particularly in the elderly.