Speciality
Spotlight

 




 


Neurology


 

 




Status
Epilepticus

          

  • DM
    Treiman, for the Veterans Affairs Status Epilepticus
    Cooperative Study Group (Veterans Affairs Med Ctr,
    West Los Angeles; Veterans Affairs med
    Ctr, Bronx, NY; Veterans Affairs Med Ctr, Birmingham,
    Ala;  et
    al)

    A
    Comparison of Four Treatments for Generalized
    Convulsive Status Epilepticus.

    N
    Engl J Med 339 : 792-798, 1998.

         

    Three
    hundred eight-four patients with a verified diagnosis
    of status epilepticus and 134 patients with subtle
    generalized convulsive status epilepticus were
    enrolled in a 5-year randomized, double-blind,
    multicentre study.

        

    The
    four intravenous drugs used were (i) diazepam,
    0.15mg/kg body weight followed by phenytoin, 18mg/kg
    (ii) Lorazepam, 0.1mg/kg  
    (iii) Phenobarbital 15mg/kg and (iv) Phenytoin,
    18mg/kg.

         

    The
    author concludes that Lorazepam is more effective than
    phenytoin
    for the initial iv
    treatment of overt generalized convulsive status
    epilepticus. Lorazepam
    is easier to use than the other agents tested.

          

 



 

 

Speciality Spotlight

 

 
Neurology
 

 

Status Epilepticus
          

  • DM Treiman, for the Veterans Affairs Status Epilepticus Cooperative Study Group (Veterans Affairs Med Ctr, West Los Angeles; Veterans Affairs med Ctr, Bronx, NY; Veterans Affairs Med Ctr, Birmingham, Ala;  et al)
    A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus.
    N Engl J Med 339 : 792-798, 1998.
         
    Three hundred eight-four patients with a verified diagnosis of status epilepticus and 134 patients with subtle generalized convulsive status epilepticus were enrolled in a 5-year randomized, double-blind, multicentre study.
        
    The four intravenous drugs used were (i) diazepam, 0.15mg/kg body weight followed by phenytoin, 18mg/kg (ii) Lorazepam, 0.1mg/kg   (iii) Phenobarbital 15mg/kg and (iv) Phenytoin, 18mg/kg.
         
    The author concludes that Lorazepam is more effective than phenytoin for the initial iv treatment of overt generalized convulsive status epilepticus. Lorazepam is easier to use than the other agents tested.
          

 

 

By |2022-07-20T16:44:13+00:00July 20, 2022|Uncategorized|Comments Off on Status Epilepticus

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