DA, Menezes AH, et al (Univ of
Iowa, Iowa City)
Treatment of Down Syndrome-Associated Craniovertebral Junction Abnormalities
J Neurosurg 93: 205-213, 2000
Down syndrome can result in various abnormalities, including a propensity for occipitoatlantal dislocations.
Surgical treatment of motion abnormalities at the craniovertebral junction (CVJ) is reported to be associated with a high incidence of morbidity.
Medical and radiographic data of 36 patients aged 3 to 49 years, treated for CVJ instability between 1976 and 1999 were reviewed for clinical outcome. It was found that outcomes were excellent in 13 (36%), good in 11(30%) and stable in 12(33%). There were no poor outcomes.
The authors conclude that surgical correction of instability of the CVJ in patients with Down syndrome can be performed with a high success rate.