Anticoagulation - MD Browse

Anticoagulation

Speciality
Spotlight

Anticoagulation

Hylec
EM, Heiman H, Skates SJ, et al [ Massachusettes Gen
Hosp, Boston, Harvard Med School, Boston ]

Acetaminophen and Other Risk Factors for Excessive
Warfarin Anticoagulation

JAMA 279: 657-662, 1998

Warfarin anticoagulation is associated with hemorrhage
when the intensity of anticoagulation is high i.e.
international normalized ratio levels greater than 4.0.

This study is of 96 participants having an INR greater
than 6.0 and 196 control participants. There was a
significant dose response relationship between
acetaminophen use and having a INR greater than 6.0. The
mechanism responsible for acetaminophen’s effect is
likely displacement of warfarin from serum proteins a
common effect of analgesics.

Speciality Spotlight

Anticoagulation

Hylec EM, Heiman H, Skates SJ, et al [ Massachusettes Gen Hosp, Boston, Harvard Med School, Boston ]
Acetaminophen and Other Risk Factors for Excessive Warfarin Anticoagulation
JAMA 279: 657-662, 1998

Warfarin anticoagulation is associated with hemorrhage when the intensity of anticoagulation is high i.e. international normalized ratio levels greater than 4.0.

This study is of 96 participants having an INR greater than 6.0 and 196 control participants. There was a significant dose response relationship between acetaminophen use and having a INR greater than 6.0. The mechanism responsible for acetaminophen’s effect is likely displacement of warfarin from serum proteins a common effect of analgesics.

By Scott Allen|2022-07-20T16:44:03+00:00July 20, 2022|Uncategorized|Comments Off

About the Author: Scott Allen

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