Speciality
Spotlight

 




 


Oncology


 

 






Anticoagulation

  

  • Hylec
    EM, Heiman H, Skates SJ, et al [ Massachusettes Gen
    Hosp, Boston, Harvard Med School, Boston ]

    Acetaminophen and Other Risk Factors for Excessive
    Warfarin Anticoagulation


    JAMA 279: 657-662, 1998

     

    Warfarin anticoagulation is associated with hemorrhage
    when the intensity of anticoagulation is high i.e.
    international normalized ratio levels greater than 4.0.

     

    This study is of 96 participants having an INR greater
    than 6.0 and 196 control participants. There was a
    significant dose response relationship between
    acetaminophen use and having a INR greater than 6.0. The
    mechanism responsible for acetaminophen’s effect is
    likely displacement of warfarin from serum proteins a
    common effect of analgesics.

      


 

 



 

 

Speciality Spotlight

 

 

Anticoagulation
  

  • Hylec EM, Heiman H, Skates SJ, et al [ Massachusettes Gen Hosp, Boston, Harvard Med School, Boston ]
    Acetaminophen and Other Risk Factors for Excessive Warfarin Anticoagulation
    JAMA 279: 657-662, 1998
     
    Warfarin anticoagulation is associated with hemorrhage when the intensity of anticoagulation is high i.e. international normalized ratio levels greater than 4.0.
     
    This study is of 96 participants having an INR greater than 6.0 and 196 control participants. There was a significant dose response relationship between acetaminophen use and having a INR greater than 6.0. The mechanism responsible for acetaminophen’s effect is likely displacement of warfarin from serum proteins a common effect of analgesics.
      

 

 

 

By |2022-07-20T16:44:03+00:00July 20, 2022|Uncategorized|Comments Off on Anticoagulation

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