P Lianes, and the National Cancer Institute Bladder Tumor Marker Network [Mem Sloan-Kettering Cancer Ctr, New York; et al]
Biomarker Study of Primary Nonmetastatic Versus Metastatic Invasive Bladder Cancer
Clin Cancer Res 4: 1267-1271, 1998
Conclusion – changes in P53 expression proliferative index, microvascular counts and ploidy status are not strongly correlated with lymph node status in patients with high-stage, high-grade bladder cancer. The association of these markers with the development of systemic metastases and death is apparently independent of disease stage.
Result of this study are surprising in that none of these markers were predictive of lymph node metastases.
This is a little starting in that several other studies previously reported each of these markers have individually been shown to a correlate with the development of systemic metastases and death.