Speciality
Spotlight

 




 


Oncology


 

 





Diagnostic
Gynaecology

    

  • Cancer
    Risk in Women Exposed to Diethylstilbestrol in Utero

    EE
    Hatch, JR Palmer, et al (Natl Cancer Inst, Bethesda, Md;
    Boston Univ; Dartmouth-Hitchcock Med Ctr, Lebanon, NH;
    et al)

    JAMA
    280 : 630-634, 1998

       


    Introduction
    – A strong association between diethylstilbestrol (DES)
    use in pregnancy and the occurrence of vaginal clear
    cell adenocarcinoma in female offspring has been
    reported in 1971.

       

    Method
    – Questionnaires were mailed to 4536 DES-exposed women
    and 1544 unexposed women first identified in the
    mid-1970s.

       

    Results
    – An increased risk for all cancers was not found among
    DES exposed women, nor was there an increased risk for
    individual cancer sites, except for clear cell
    adenocarcinoma.

       

    Conclusion
    drawn from this study is that 
    exposed women included in this study were a mean
    of 38 years; therefore, continued 
    surveillance is warranted to determine whether
    any increases in cancer risk occur during the menopausal
    years.

       

    Editorial
    comment:
    clinicians
    should be aware that vaginal clear cell adenocarcinomas
    are being observed in the DES-exposed up to the age of
    48 years. The
    above cohort was, on average, only 38 years of age at
    the time of follow-up, so it will be important to follow
    these individuals for many years to understand their
    health risks.

      


 

 



 

 

Speciality Spotlight

 

 

Diagnostic Gynaecology
    

  • Cancer Risk in Women Exposed to Diethylstilbestrol in Utero
    EE Hatch, JR Palmer, et al (Natl Cancer Inst, Bethesda, Md; Boston Univ; Dartmouth-Hitchcock Med Ctr, Lebanon, NH; et al)
    JAMA 280 : 630-634, 1998
       
    Introduction – A strong association between diethylstilbestrol (DES) use in pregnancy and the occurrence of vaginal clear cell adenocarcinoma in female offspring has been reported in 1971.
       
    Method – Questionnaires were mailed to 4536 DES-exposed women and 1544 unexposed women first identified in the mid-1970s.
       
    Results – An increased risk for all cancers was not found among DES exposed women, nor was there an increased risk for individual cancer sites, except for clear cell adenocarcinoma.
       
    Conclusion drawn from this study is that  exposed women included in this study were a mean of 38 years; therefore, continued  surveillance is warranted to determine whether any increases in cancer risk occur during the menopausal years.
       
    Editorial comment: clinicians should be aware that vaginal clear cell adenocarcinomas are being observed in the DES-exposed up to the age of 48 years. The above cohort was, on average, only 38 years of age at the time of follow-up, so it will be important to follow these individuals for many years to understand their health risks.
      

 

 

 

By |2022-07-20T16:43:57+00:00July 20, 2022|Uncategorized|Comments Off on Diagnostic Gynaecology

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