Koch WM, Lango M, Sewell D, et al (Johns Hopkins Med Institutions, Baltimore, MD)
Head and Neck Cancer in Nonsmokers: A Distinct Clinical and Molecular Entity.
Laryngoscope 109: 1544-1551, 1999
Several target genes have been identified for head and neck squamous cell carcinoma (HNSCC), including p53, p15, RB, and cyclin D1. The molecular evidence for the location of tumour suppressor genes (still undiscovered) is provided by loss of heterozygosity (LOH).
The genetic makeup of nonsmokers may provide valuable information of tumorigenesis. Molecular patterns were studied in smokers and nonsmokers.
All 305 patients with smokers, nonsmoker and previous smokers were studied.
The molecular pattern was distinct in two groups, smokers were more likely to have tumours with p53 mutation, LOH at chromosome 3p, 4q, and 11q13, and a higher overall percentage of microsatellite alterations. The rate of human papillomavirus (HPV) infection was barely higher in tumours of nonsmokers.
Xie X, Boysen M, Clausen OPF, et al (Natl Hosp, Oslo, Norway; Univ of Oslo, Norway)
Prognostic Value of Ley and H Antigens in Oral Tongue Carcinomas
Laryngoscope 109: 1474-1480, 1999
Eight randomly selected T1-T4 oral tongue squamous cell carcinoma were studied.
Expression of H Antigens and Ley, particularly their combination with proliferative or apoptotic markers, has prognostic value in oral tongue carcinoma.
Bjork-Eriksson T, West CML, et al (Sahlgrenska Univ, Gothenburg, Sweden; Univ of Gothenburg, Sweden; Christie (CRC) Research Centre,Machester, England)
The Lack of Correlation Between Proliferation (Ki-67, PCNA, LI, Tpot), p53 Expression and Radiosensitivity for Head and Neck Cancers.
Br J Cancer 80: 1400-1404, 1999
The relationship between SF2,various proliferation parameters (Ki-67,PCNA, LI, Tpot) and p53 expression was examined in 77 patients with head and neck cancers.
The longstanding assumption that rapidly proliferating cancer pathology is radiosensitive is not substantiated. These findings suggest that multiple measurements of radiobiological parameters may have to be conducted with head and neck cancer patients to determine radiosensitivity.
Editor -R.A. Otto comment’s: If this could be achieved, tailored treatment regimens, improved tumour control, and reduced morbidity – could be achieved. This brings to intrinsic radiosensitivity and proliferation of cells.
Clayman GL, Frank DK, Bruso PA, et al (Univ of Texas, Houston)
Adenovirus-mediated Wild-type p53 Gene Transfer as a Surgical Adjuvant in Advanced Head and Neck Cancers.
Clin Cancer Res 5: 1715-1722, 1999
With all modern treatments, advanced head and neck survival rate is 50% because of high incidence of locoregional failure. Preclinical studies suggest that gene transfer techniques using recombinant p53 adenovirus (Ad-p53) may provide a new therapeutic approach.
At phase I trial in such patients with locoregional recurrence, this therapy was feasible and tolerable. Fifteen patients were treated with this transfer technique and surgery followed. This treatment had low toxicity.
Editor- R.A. Otto comment’s: Theoretically, the virus should spread, induce genetic changes lethal to tumour cells but spare normal cells.