Kirita T, Ohgi K, Shimooka H, et al [ Nara Med Univ, Japan]
Preoperative Concurrent Chemoradiotherapy plus Radical Surgery for Advanced Squamous Cell Carcinoma of the Oral Cavity: An analysis of Long-term Results
Oral Oncol 35: 597-606, 1999 Pg.No. 242
The patients all had advanced, but potentially resectable, squamous cell carcinoma of the oral cavity, including, the soft palate. All had a tumor size of at least 30 mm; regional lymph node involvement was acceptable.
All received concurrent cisplatin – or carboplatin-based chemotherapy with stimultaneous radiation therapy [target volume, 40 Gy].
At an average follow-up of 7 years, the patients were evaluated for late toxicity, locoregional control, distant metastases, second primary malignancies, are survival.
Ten-year progression-free survival by histopathologic grade after preoperative chemoradiotherapy was 40% for patients in grade IIa, 89% for those in grade IIb, 100% for those in grade III, and 88% for those in grade IV.
The association between histologic regression grade and survival persisted on long-term analysis.
Long-term results support the use of preoperative concurrent chemoradiotherapy for patients with advanced squamous cell cancer of the oral cavity.